Systemic lupus erythematosus (SLE) is an agnogenic progressive and recurrent autoimmune
disease involving poly-organs of human beings. The epigenetic aberration plays an
important part in the immune disorder of SLE [
[1]
]. It is well known that methylation of CpG dinucleotides in the promoter and first
exon of genes is a crucial epigenetic modulation for transcriptional regression [
[2]
]. Correspondingly, hypomethylation contributes a lot for the over expression of some
genes that might lead to autoimmunity in SLE [
[3]
]. Maintenance of the methylation patterns mainly depends on methylating and demethylating
processes. DNA methyltransferases (DNMTs: DNMT-1, DNMT-3A, and DNMT-3B) [
[4]
] are responsible for formation and maintaining of methylation pattern. Methyl cytosine-binding
proteins (MBPs: MBD-1, MBD-2, MBD-3, MBD-4, and MeCP-2) are another potential factors
responsible for transcription regression [
[5]
]. Interestingly, MBD-2 is the only member that was reported with functions of both
transcriptional repressor and DNA demethylase. To determine their influence in the
onset of SLE, this paper comparatively analyzed mRNA transcriptional levels of DNMTs,
MBDs, lymphocyte function-associated antigen-1 (LFA-1) genes and their relationship
in active SLE (SLE-a) and relieved SLE (SLE-r).Keywords
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References
- Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus.J Appl Genet. 2004; 45 (Review): 237-248
- DNA methylation: its contribution to systemic lupus erythematosus.Clin Exp Med. 2006; 6 (Review): 99-106
- Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus.Arthritis Rheum. 2002; 46: 1282-1291
- The role of mammalian DNA methyltransferases in the regulation of gene expression.Cell Mol Biol Lett. 2005; 10 ([review]): 631-647
- Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients.J Leukoc Biol. 2007; 81: 1609-1616
- Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells.Mol Cell Biol. 2004; 24: 8862-8871
- Promoter-specific activation and demethylation by MBD2/demethylase.J Biol Chem. 2002; 277: 35791-35794
Article info
Publication history
Published online: July 12, 2010
Received:
July 1,
2008
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
