Systemic lupus erythematosus (SLE) is an agnogenic progressive and recurrent autoimmune disease involving poly-organs of human beings. The epigenetic aberration plays an important part in the immune disorder of SLE [
]. It is well known that methylation of CpG dinucleotides in the promoter and first exon of genes is a crucial epigenetic modulation for transcriptional regression [
- Januchowski R.
- Prokop J.
- Jagodziński P.P.
Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus.
J Appl Genet. 2004; 45 (Review): 237-248
]. Correspondingly, hypomethylation contributes a lot for the over expression of some genes that might lead to autoimmunity in SLE [
- Sekigawa I.
- Kawasaki M.
- Ogasawara H.
- Kaneda K.
- Kaneko H.
- Takasaki Y.
- et al.
DNA methylation: its contribution to systemic lupus erythematosus.
Clin Exp Med. 2006; 6 (Review): 99-106
]. Maintenance of the methylation patterns mainly depends on methylating and demethylating processes. DNA methyltransferases (DNMTs: DNMT-1, DNMT-3A, and DNMT-3B) [
- Lu Q.
- Kaplan M.
- Ray D.
- Ray D.
- Zacharek S.
- Gutsch D.
- et al.
Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus.
Arthritis Rheum. 2002; 46: 1282-1291
] are responsible for formation and maintaining of methylation pattern. Methyl cytosine-binding proteins (MBPs: MBD-1, MBD-2, MBD-3, MBD-4, and MeCP-2) are another potential factors responsible for transcription regression [
- Turek-Plewa J.
- Jagodzinski P.P.
The role of mammalian DNA methyltransferases in the regulation of gene expression.
Cell Mol Biol Lett. 2005; 10 ([review]): 631-647
]. Interestingly, MBD-2 is the only member that was reported with functions of both transcriptional repressor and DNA demethylase. To determine their influence in the onset of SLE, this paper comparatively analyzed mRNA transcriptional levels of DNMTs, MBDs, lymphocyte function-associated antigen-1 (LFA-1) genes and their relationship in active SLE (SLE-a) and relieved SLE (SLE-r).
- Balada E.
- Ordi-Ros J.
- Serrano-Acedo S.
- Martinez-Lostao L.
- Vilardell-Tarrés M.
Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients.
J Leukoc Biol. 2007; 81: 1609-1616
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- Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus.J Appl Genet. 2004; 45 (Review): 237-248
- DNA methylation: its contribution to systemic lupus erythematosus.Clin Exp Med. 2006; 6 (Review): 99-106
- Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus.Arthritis Rheum. 2002; 46: 1282-1291
- The role of mammalian DNA methyltransferases in the regulation of gene expression.Cell Mol Biol Lett. 2005; 10 ([review]): 631-647
- Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients.J Leukoc Biol. 2007; 81: 1609-1616
- Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells.Mol Cell Biol. 2004; 24: 8862-8871
- Promoter-specific activation and demethylation by MBD2/demethylase.J Biol Chem. 2002; 277: 35791-35794
Published online: July 12, 2010
Received: July 1, 2008
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.