Absorption of food allergens from the intestinal tract is thought to be important
in the development of food allergies. A recent report showed that intestinal permeability
to macromolecules was increased in patients with adverse reactions to food [
[1]
]. Passage of intact dietary allergens, such as β-lactoglobulin and ovalbumin in meal,
into the blood has been documented [
[2]
]. In our previous study, we demonstrated that the circulating levels of gliadin, which
is recognized as an allergen for a variety of wheat allergies, were correlated with
the clinical symptoms in patients with wheat-dependent exercise-induced anaphylaxis
(WDEIA) [
3
,
4
]. Interestingly, increased serum gliadin levels induced by exercise and aspirin were
also observed in healthy subjects. In addition, a recent case report described a patient
with WDEIA induced by low-dose aspirin therapy for secondary prevention of cardiovascular
events [
[5]
]. Intake of aspirin enhances intestinal permeability, which is associated with gastrointestinal
disorders [
[6]
]. Thus, it is hypothesized that aspirin facilitates the absorption of intact gliadin
due to an increase in gastrointestinal permeability. However, the dose effects of
aspirin and administration of other non-steroidal anti-inflammatory drugs (NSAIDs)
on the absorption of wheat gliadin remain unclear. The purpose of the present study
was to evaluate the effects of administration of low-dose aspirin and conventional-dose
of diclofenac, loxoprofen and meloxicam on serum gliadin levels after wheat ingestion
in healthy subjects.Keywords
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References
- Intestinal permeability in patients with adverse reactions to food.Dig Liver Dis. 2006; 38: 732-736
- Passage of undegraded dietary antigen into the blood of healthy adults. Further characterization of the kinetics of uptake and the size distribution of the antigen.Scand J Immunol. 1986; 24: 447-455
- Exercise and aspirin increase levels of circulating gliadin peptides in patients with wheat-dependent exercise-induced anaphylaxis.Clin Exp Allergy. 2005; 35: 461-466
- Food-dependent exercise-induced anaphylaxis.J Dermatol Sci. 2007; 47: 109-117
- Food-dependent exercise-induced anaphylaxis induced by low dose aspirin therapy.Allergol Int. 2008; 57: 97-98
- Effect of aspirin and ibuprofen on GI permeability during exercise.Int J Sports Med. 2007; 28: 722-726
- Sensitivity and specificity of recombinant ω-5 gliadin-specific IgE measurement for the diagnosis of wheat-dependent exercise-induced anaphylaxis.Allergy. 2008; 63: 233-236
- Semi-purification of the immunoglobulin E-sweat antigen acting on mast cells and basophils in atopic dermatitis.Exp Dermatol. 2006; 15: 283-290
- Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs.Gut. 2001; 49: 650-655
- Safety of meloxicam: a global analysis of clinical trials.Br J Rheumatol. 1996; 35: 68-77
Article info
Publication history
Published online: July 12, 2010
Received:
May 29,
2008
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
