Absorption of food allergens from the intestinal tract is thought to be important in the development of food allergies. A recent report showed that intestinal permeability to macromolecules was increased in patients with adverse reactions to food [
]. Passage of intact dietary allergens, such as β-lactoglobulin and ovalbumin in meal, into the blood has been documented [
- Ventura M.T.
- Polimeno L.
- Amoruso A.C.
- Gatti F.
- Annoscia E.
- Marinaro M.
- et al.
Intestinal permeability in patients with adverse reactions to food.
Dig Liver Dis. 2006; 38: 732-736
]. In our previous study, we demonstrated that the circulating levels of gliadin, which is recognized as an allergen for a variety of wheat allergies, were correlated with the clinical symptoms in patients with wheat-dependent exercise-induced anaphylaxis (WDEIA) [
- Husby S.
- Jensenius J.C.
- Svehag S.E.
Passage of undegraded dietary antigen into the blood of healthy adults. Further characterization of the kinetics of uptake and the size distribution of the antigen.
Scand J Immunol. 1986; 24: 447-455
- Matsuo H.
- Morimoto K.
- Akaki T.
- Kaneko S.
- Kusatake K.
- Kuroda T.
- et al.
Exercise and aspirin increase levels of circulating gliadin peptides in patients with wheat-dependent exercise-induced anaphylaxis.
Clin Exp Allergy. 2005; 35: 461-466
4]. Interestingly, increased serum gliadin levels induced by exercise and aspirin were also observed in healthy subjects. In addition, a recent case report described a patient with WDEIA induced by low-dose aspirin therapy for secondary prevention of cardiovascular events [
- Morita E.
- Kunie K.
- Matsuo H.
Food-dependent exercise-induced anaphylaxis.
J Dermatol Sci. 2007; 47: 109-117
]. Intake of aspirin enhances intestinal permeability, which is associated with gastrointestinal disorders [
- Fujii H.
- Kambe N.
- Fujisawa A.
- Kohno K.
- Morita E.
- Miyachi Y.
Food-dependent exercise-induced anaphylaxis induced by low dose aspirin therapy.
Allergol Int. 2008; 57: 97-98
]. Thus, it is hypothesized that aspirin facilitates the absorption of intact gliadin due to an increase in gastrointestinal permeability. However, the dose effects of aspirin and administration of other non-steroidal anti-inflammatory drugs (NSAIDs) on the absorption of wheat gliadin remain unclear. The purpose of the present study was to evaluate the effects of administration of low-dose aspirin and conventional-dose of diclofenac, loxoprofen and meloxicam on serum gliadin levels after wheat ingestion in healthy subjects.
- Lambert G.P.
- Boylan M.
- Laventure J.P.
- Bull A.
- Lanspa S.
Effect of aspirin and ibuprofen on GI permeability during exercise.
Int J Sports Med. 2007; 28: 722-726
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- Intestinal permeability in patients with adverse reactions to food.Dig Liver Dis. 2006; 38: 732-736
- Passage of undegraded dietary antigen into the blood of healthy adults. Further characterization of the kinetics of uptake and the size distribution of the antigen.Scand J Immunol. 1986; 24: 447-455
- Exercise and aspirin increase levels of circulating gliadin peptides in patients with wheat-dependent exercise-induced anaphylaxis.Clin Exp Allergy. 2005; 35: 461-466
- Food-dependent exercise-induced anaphylaxis.J Dermatol Sci. 2007; 47: 109-117
- Food-dependent exercise-induced anaphylaxis induced by low dose aspirin therapy.Allergol Int. 2008; 57: 97-98
- Effect of aspirin and ibuprofen on GI permeability during exercise.Int J Sports Med. 2007; 28: 722-726
- Sensitivity and specificity of recombinant ω-5 gliadin-specific IgE measurement for the diagnosis of wheat-dependent exercise-induced anaphylaxis.Allergy. 2008; 63: 233-236
- Semi-purification of the immunoglobulin E-sweat antigen acting on mast cells and basophils in atopic dermatitis.Exp Dermatol. 2006; 15: 283-290
- Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs.Gut. 2001; 49: 650-655
- Safety of meloxicam: a global analysis of clinical trials.Br J Rheumatol. 1996; 35: 68-77
Published online: July 12, 2010
Received: May 29, 2008
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.