The chemotatic factor, IL-8 (CXCL8), is central to neutrophil recruitment to the skin
in acute inflammation and chronic diseases like psoriasis. To attract circulating
leukocytes, chemokines produced by resident tissue cells must traverse an endothelial
barrier. Upon intradermal injection, IL-8 was undetectable at cell-to-cell contacts
but rather traversed the microvasculature by way of caveolae in association with caveolin-1
in the cytoplasm of endothelial cells (ECs), a pattern suggestive of a transcellular,
rather than pericellular, mode of transport [
[1]
]. Recombinant chemokines ELC, RANTES, and MCP-1, were also found to be internalized
by uncoated vesicular structures in the endothelium, supporting the current paradigm
that chemokine transport or “transcytosis” occurs by way of caveolae [
1
,
2
,
3
].Keywords
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References
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Article info
Publication history
Published online: July 12, 2010
Received:
April 5,
2008
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
