T helper 17 (Th17) plays a pivotal role in the pathogenesis of autoimmune diseases,
such as autoimmune encephalitis and inflammatory bowel diseases, in which Th1 previously
were thought essential [
1
,
2
,
3
]. Also, previous reports have suggested that interleukin (IL)-17 is a crucial factor
in the homing of granulocytes and tissue injury in bronchial asthma [
4
,
5
], which is believed to be a Th2 type disease. However, it has never been investigated
whether Th17 is involved in autoimmune bullous diseases. We have here, for the first
time, evaluated the status of lesional Th17 and T regulatory (Treg) cells immunohistochemically
in pemphigus vulgaris and pemphigus foliaceus.Keywords
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References
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- Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions.J Allergy Clin Immunol. 2003; 111: 875-881
- CD4+CD25 high regulatory T cells are markedly decreased in blood of patients with pemphigus vulgaris.Dermatology. 2007; 214: 210-220
- Production of epidermal acantholysis in normal human skin in vitro by the IgG fraction from pemphigus serum.J Invest Dermatol. 1976; 67: 254-260
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Article info
Publication history
Published online: July 12, 2010
Received:
March 19,
2008
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
