Progranulin (PGRN) is a secreted growth factor implicated in a wide variety of biological
processes including tumorigenesis, tissue maintenance, sexual differentiation of the
brain, and embryo development [
1
,
2
]. It has been recently shown that mutations in PGRN cause a subtype of familial frontotemporal
lobar degeneration [
3
,
4
]. However, investigation of PGRN functions at the whole organism level is largely
limited.Keywords
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References
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- Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.Nature. 2006; 442: 920-924
- Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development..Proc Natl Acad Sci USA. 1997; 94: 7400-7405
- Cellular localization of gene expression for progranulin.J Histochem Cytochem. 2000; 48: 999-1009
- Patterns of proliferation and apoptosis during murine hair follicle morphogenesis.J Invest Dermatol. 2001; 116: 947-955
- Keratinocyte survival, differentiation, and death: many roads lead to mitogen-activated protein kinase.J Invest Dermatol Symp Proc. 2002; 7: 36-40
- Keratinocyte apoptosis in epidermal development and disease.J Invest Dermatol. 2006; 126: 243-257
- An investigation of apoptosis in androgenetic alopecia.Am J Dermatopathol. 2002; 24: 204-208
Article info
Publication history
Published online: July 12, 2010
Received:
May 13,
2008
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
