Abstract
Background
Studies on the pathogenesis of skin ageing as well as efficacy testing of cosmetic
and aesthetic measures to prevent or reverse skin ageing require – as an easy to use
method – a validated non-invasive clinical score, which allows to simultaneously assess
and differentiate between intrinsic (=chronological) and extrinsic (=photo-) skin
ageing. Such an ideal score, however, does currently not exist.
Objectives
We developed a novel skin ageing score ‘SCINEXA’ comprising 5 items indicative of
intrinsic and 18 items highly characteristic of extrinsic skin ageing. These items
were used to define an index (indexdiscr) that allowed differentiating between intrinsic versus extrinsic skin ageing. In
order to validate the ‘SCINEXA’, we asked whether it can be used to discriminate regular
sunbed users, which have been chronically exposed to ultraviolet radiation and thus
are prone to photoageing, from non-sunbed users, which were considered paradigmatic
for intrinsic skin ageing.
Methods
For this purpose, 58 non-sunbed users and 16 regularly sunbed users were assessed.
In addition to the clinical examination of the 23 score items potential confounders
were considered by questionnaire.
Results
By employing the indexdiscr, we were able to classify 92% of all study subjects correctly as sunbed or non-sunbed
users. Specifically, an index above 2 was associated with sunbed use and thus extrinsic
skin ageing, whereas an index below 2 indicated intrinsic skin ageing.
Conclusion
The novel ‘SCINEXA’ is suitable for the simultaneous assessment of intrinsic and extrinsic
skin ageing.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Dermatological ScienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The new science of perfect skin: understanding skin care myths and miracles for radiant skin at any age.Broadway Books, New York2008
- Relative contribution of intrinsic vs extrinsic factors to skin ageing as determined by a validated skin age score.Arch Dermatol. 2002; 138: 1454-1460
- Smoker's wrinkles. A study in the epidemiology of “crow's feet”.Ann Intern Med. 1971; 75: 873-880
- A photonumeric scale for the assessment of cutaneous photodamage.Arch Dermatol. 1992; 128: 347-351
- Evaluation of cutaneous photodamage using a photographic scale.Br J Dermatol. 1994; 130: 167-173
- A photographic scale for the assessment of human facial wrinkles.J Cosmet Sci. 2000; 51: 127-139
- The wrinkle severity rating scale.Am J Clin Dermatol. 2004; 5: 49-52
- Photoaging of the connective tissue of skin: its prevention and therapy.Adv Pharmacol. 1977; 38: 639-655
- Photoaging.in: Dermatology in General Medicine. vol. II. Mc Graw-Hill, New York, NY1993: 2972-2979
- Premature ageing of the skin in a Queensland population.Med J Aust. 1991; 155 (477n 478): 473-474
- Clinical and histological features of intrinsic versus extrinsic skin aging.in: Gilchrest B.A. Krutmann J. Skin Aging. Springer-Verlag, Berlin, Heidelberg2006: 9-21
- Elderly and sun-affected skin.Can Fam Phys. 2001; 47: 1236-1243
- Skin aging: postulated mechanisms and consequent changes in structure and function.Clin Geriatr Med. 2001; 17: 617-630
- Photoaging.in: Lim H. Soter N. Clinical photomedicine. Marcel Dekker, New York1993: 95-111
- Photoageing: mechanism, prevention and therapy.Br J Dermatol. 2007; 157: 874-887
- Can skin wrinkling in a site that has received limited sun exposure be used as a marker of health status and biological age?.Age Ageing. 2001; 30: 227-234
- Skin ageing induced by ultraviolet exposure and tobacco smoking: evidence from epidemiological and molecular studies.Photodermatol Photoimmunol Photomed. 2001; 17: 178-183
- The validity and practicality of sun-reactive skin types I through VI.Arch Dermatol. 1988; 124: 869-871
- Determinants of spot and wrinkle formation in German and Japanese women.J Invest Dermatol. 2008; S1: S80
- Sunbed use induces the photoaging-associated mitochondrial common deletion.J Invest Dermatol. 2008; 128: 1294-1297
Scientific Committee on Consumer Products, European Commission (2006) opinion on biological effects of ultraviolet radiation reveal to health with particular reference to sunbeds for cosmetic purposes. http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs(sccp_o_031b.pdf (accessed 2007).
Article info
Publication history
Published online: July 12, 2010
Accepted:
October 6,
2008
Received in revised form:
September 29,
2008
Received:
July 7,
2008
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
