GLI1 oncogene mediates the effects of the signalling molecule Sonic Hedgehog, involved
in the control of differentiation and morphogenesis during embryonic development and
postnatal life [
1
,
2
]. Methods to modulate GLI1 expression without knocking out the gene have not yet been devised. Since GLI1 is specifically expressed by basal cell carcinoma (BCC) [
2
,
3
], which expression is considered a diagnostic hallmark and a pathogenetically meaningful
event [
[4]
], BCC cells might be valuable to investigate on GLI1 modulation and its consequences.Keywords
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References
- The sonic hedgehog-patched-gli pathway in human development and disease.Am J Hum Genet. 2000; 67: 1047-1054
- Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin.J Invest Dermatol. 1999; 113: 595-599
- Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1.Br J Dermatol. 1998; 139: 911-915
- Molecular diagnosis of basal cell carcinoma and other basaloid cell neoplasms of the skin by the quantification of Gli1 transcript levels.J Cutan Pathol. 2005; 32: 131-136
- Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.Transplant Proc. 1987; 19: 4-8
- Are keloids really “gli-loids”?: High-level expression of gli-1 oncogene in keloids.J Am Acad Dermatol. 2001; 45: 707-711
- GLI-1 oncogene is highly expressed in granulomatous skin disorders, including sarcoidosis, granuloma annulare, and necrobiosis lipoidica diabeticorum.Arch Dermatol. 2005; 141: 259-262
- Signalling mechanisms of anoikis.Histol Histopathol. 2004; 19: 973-983
- The expanding role of topical tacrolimus in dermatology.Clin Exp Dermatol. 2005; 30: 111-115
- Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin.Br J Dermatol. 2003; 149: 960-967
Article info
Publication history
Published online: July 12, 2010
Accepted:
October 25,
2008
Received in revised form:
October 6,
2008
Received:
May 13,
2008
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
