Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by large, tense blisters. Production of autoantibodies against the 180-kDa hemidesmosomal protein of the basement membrane zone is regarded as the first event of the pathomechanism [
]. Once the autoantibodies bind to the basement membrane, a cascade of inflammatory events occurs, resulting in subsequent blister formation at the dermoepidermal junction. During this process, cytokines and chemokines are considered to play crucial roles in inflammatory cell recruitment, deposition and perpetuation [
- Labib R.S.
- Anhalt G.J.
- Patel H.P.
- Mutasim D.F.
- Diaz L.A.
Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting.
J Immunol. 1986; 136: 1231-1235
]. Therefore, clarifying the serum and local levels of cytokines and chemokines may help in understanding the immune dysregulation in the pathomechanism of BP.
- Pastore S.
- Mascia F.
- Mariotti F.
- Dattilo C.
- Girolomoni G.
Chemokine networks in inflammatory skin diseases.
Eur J Dermatol. 1994; 130: 128-129
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- Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting.J Immunol. 1986; 136: 1231-1235
- Chemokine networks in inflammatory skin diseases.Eur J Dermatol. 1994; 130: 128-129
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- Bullous pemphigoid, an ultrastructural study of the inflammatory response: eosinophil, basophil and mast cell granule changes in multiple biopsies from one patient.J Invest Dermatol. 1982; 78: 91-101
- IgG4 and IgE are the major immunoglobulins targeting the NC16A domain of BP180 in Bullous pemphigoid: serum levels of these immunoglobulins reflect disease activity.J Am Acad Dermatol. 2000; 42: 577-583
Published online: July 12, 2010
Received: March 18, 2008
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.