Pemphigus comprises a group of autoimmune blistering diseases affecting the skin and/or
mucous membranes [
[1]
]. The blister formation in pemphigus has been elucidated markedly and shown to be
caused by autoantibodies against desmoglein 1 (Dsg 1) and desmoglein 3 (Dsg 3) [
[2]
]. On the other hand, morphological studies using electron microscope on pemphigus
were performed in 1960s [
3
,
4
,
5
], when little was known about their underlying molecular pathophysiology. Now the
changes of desmosome-keratin cytoskeleton have come to the central point of discussion
as the cause of acantholysis, it is necessary and timely to re-evaluate the ultrastructural
changes in pemphigus, particularly focusing to the changes of desmosomes and cytoskeletal
structures.To read this article in full you will need to make a payment
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References
- Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome.N Engl J Med. 2006; 355: 1800-1810
- The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile.J Am Acad Dermatol. 1999; 40: 167-170
- An electron microscopic study on pemphigus vulgaris of the mouth and the skin with special reference to the intercellular cement.J Invest Dermatol. 1967; 48: 540-552
- The intercellular cement in pemphigus vulgaris, an electron microscopic study.Dermatologica. 1967; 135: 27-34
- An electron microscopic study of acantholysis in pemphigus vulgaris.J Invest Dermatol. 1961; 36: 373-382
- Ultrastructural studies of allergic contact dermatitis in man. Epidermal cell changes at 3, 6, 12 h after application of DNCB.Arch Dermatol Res. 1980; 267: 275-282
- Keratin intermediate filament retraction is linked to plakoglobin-dependent signaling in pemphigus vulgaris.J Am Acad Dermatol. 2007; 56 (890-1-2)
- IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model.J Invest Dermatol. 2004; 122: 1145-1153
- A novel explanation for acantholysis in pemphigus vulgaris: the basal cell shrinkage hypothesis.J Am Acad Dermatol. 2006; 54: 513-516
Article info
Publication history
Published online: July 12, 2010
Received:
August 21,
2008
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
