Letter to the Editor| Volume 54, ISSUE 1, P48-49, April 2009

No involvement of non-synonymous TLR2 polymorphisms in Japanese leprosy patients

      Leprosy (Hansen's disease) is a chronic infectious disease caused by Mycobacterium (M.) leprae, and primarily affects the skin and the peripheral nerve. Although M. leprae are weak in its infectious potency, leprosy has been feared because of the accompanying visible disfigurement and functional defects. In Japan, leprosy patients had been forcedly isolated in leprosaria for 100 years based on the Law for Prevention of Leprosy. Although the Law has been repealed in 1996, most of the patients are already too old to live apart from leprosaria. Nowadays, only few Japanese patients newly occur, whereas 700,000 leprosy patients are still added worldwide per year, mostly in the developing countries.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Dermatological Science
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Underhill D.M.
        • Ozinsky A.
        • Smith K.D.
        • Aderem A.
        Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.
        Proc Natl Acad Sci USA. 1999; 96: 14459-14463
        • Krutzik S.R.
        • Ochoa M.T.
        • Sieling P.A.
        • Uematsu S.
        • Ng Y.W.
        • Legaspi A.
        • et al.
        Activation and regulation of Toll-like receptor 2 and 1 in human leprosy.
        Nat Med. 2003; 9: 525-532
        • Kang T.J.
        • Chae G.T.
        Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients.
        FEMS Immunol Med Microbiol. 2001; 31: 53-58
        • Kang T.J.
        • Yeum C.E.
        • Kim B.C.
        • You E.Y.
        • Chae G.T.
        Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation.
        Immunology. 2004; 112: 674-680
        • Bochud P.Y.
        • Hawn T.R.
        • Aderem A.
        Role of a TLR2 polymorphism in mycobacterial infection.
        J Immunol. 2003; 170: 3451-3454
        • Ben-Ali M.
        • Barbouche M.R.
        • Bousnina S.
        • Chabbou A.
        • Dellagi K.
        Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.
        Clin Diagn Lab Immunol. 2004; 11: 625-626
        • Malhotra D.
        • Relhan V.
        • Reddy B.S.N.
        • Bamezai R.
        TLR2 Arg677Trp polymorphism in leprosy: revisited.
        Hum Genet. 2005; 116: 413-415
        • Ogus A.C.
        • Yoldas B.
        • Ozdemir T.
        • Uguz A.
        • Olcen S.
        • Keser I.
        • et al.
        The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease.
        Eur Respir J. 2004; 23: 219-223
        • Veltkamp M.
        • Wijnen P.A.
        • van Moorsel C.H.
        • Rijkers G.T.
        • Ruven H.J.
        • Heron M.
        • et al.
        Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis.
        Clin Exp Immunol. 2007; 149: 453-462
        • Bochund P.Y.
        • Hawn T.R.
        • Siddiqui M.R.
        • Saunderson P.
        • Britton S.
        • Abraham I.
        • et al.
        Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.
        J Infect Dis. 2008; 197: 253-261