Abstract
Background
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that plays
an important part in the pathogenesis of autoimmune diseases. A high level of MIF
has been detected in plaques of psoriasis and the sera of patients with psoriasis.
Polymorphisms associated with autoimmune and inflammatory diseases exist in the promoter
region of MIF and alter its expression.
Objective
The aim of this study was to evaluate the potential relationship between functional
polymorphisms of MIF and psoriasis in a Han population in northeastern China.
Methods
Two-hundred-and-forty psoriasis patients and a control group of 269 healthy volunteers
were included in this study. We genotyped MIF-173G/C using polymerase chain reaction-restriction
fragment length polymorphism (PCR-RFLP). MIF-794CATT5–8 microsatellite polymorphism was genotyped by polyacrylamide gel electrophoresis (PAGE).
Results
No significant difference in the distributions of alleles, genotypes and haplotypes
was observed between patients and controls. When patients were divided into subtypes
according to sex, family history and age of onset, distribution of the MIF-173C allele
between male and female patients was significantly different (P= 0.04). MIF-173C allelic distribution between late onset psoriasis patients and controls
was also different (P = 0.02), as well as late onset patients and early onset subjects (P= 0.04).
Conclusions
These results suggested a preliminary association between the MIF-173C allele and
male psoriasis and late onset psoriasis in the studied population. In addition, the
distributions of the two polymorphisms in Asian populations were quite different from
the other continental populations.
Keywords
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Article info
Publication history
Published online: July 12, 2010
Accepted:
November 13,
2008
Received in revised form:
November 10,
2008
Received:
August 6,
2008
Identification
Copyright
© 2008 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
