Although epidemiologic survey revealed an association between psoriasis and obesity/adiposity
[
[1]
], no reports are present on the relationship in Japanese psoriasis patients. Obesity
induces overproduction of inflammatory cytokines such as tumor necrosis factor α (TNF-α),
interleukin (IL)-6, and IL-8 in adipose tissue. The serum levels of TNF-α, IL-6, and
IL-8 are increased in psoriasis and are associated with the disease severity [
[2]
]. Adipocytes also produce leptin, which acts primarily through the specific receptors
at hypothalamus [
[3]
]. Leptin decreases appetite and increases energy expenditure and serum levels of leptin
are known to reflect the body fat mass [
[3]
]. Adiponectin is another adipocyte-specific secretary protein abundantly present in
circulation. Plasma levels of adiponectin are paradoxically decreased in obesity,
insulin-resistance [
[4]
], and hypoadiponectinemia is closely associated with metabolic syndrome [
[5]
]. Recent study demonstrated that adiponectin and TNF-α suppress each other's production
and also antagonize each other's function in their target cells [
[6]
]. We have shown the increased plasma leptin levels and decreased adiponectin levels
in Japanese psoriasis patients [
[7]
].Keywords
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References
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Article info
Publication history
Published online: July 12, 2010
Received:
May 15,
2008
Identification
Copyright
© 2008 Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Introduction to ErratumJournal of Dermatological ScienceVol. 55Issue 1
- Erratum to “Prevalence of obesity/adiposity in Japanese psoriasis patients: Adiposity is correlated with the severity of psoriasis” [J. Dermatol. Sci. 54 (2009) 61–63]Journal of Dermatological ScienceVol. 55Issue 1
- PreviewAlthough epidemiologic survey revealed an association between psoriasis and obesity/adiposity [1], no reports are present on the relationship in Japanese psoriasis patients. Obesity induces overproduction of inflammatory cytokines such as tumor necrosis factor α (TNF-α), interleukin (IL)-6, and IL-8 in adipose tissue. The serum levels of TNF-α, IL-6, and IL-8 are increased in psoriasis and are associated with the disease severity [2]. Adipocytes also produce leptin, which acts primarily through the specific receptors at hypothalamus [3].
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