Abstract
Current research on the complex interplay between the microbiota, the barrier function
and the innate immune system of the skin indicates that the skin's microbiota have
a beneficial role, much like that of the gut microflora. As a consequence, interest
in strategies beyond antibiotica that allow a more selective modulation of the skin
microflora is constantly growing. This review will briefly summarize our current understanding
of the cutaneous microbiota and summarize existing information on pre- and probiotic
strategies for skin.
Keyword
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References
- Dietary modulation of the human conic micribiota: introducing the concept of prebiotics.J Nutr. 1995; 125: 1401-1412
- Skin microbiota: a source of disease or defense?.Brit J Dermatol. 2008; 158: 442-455
- Biology and clinical relevance of naturally occurring antimicrobial peptides.J Allergy Clin Immunol. 2002; 110: 823-831
- Stratum corneum defensive functions: an integrated view.J Invest Dermatol. 2005; 125: 183-200
- Interactions among stratum cormeum defensive functions.Exp Dermatol. 2005; 14: 719-726
- Probiotis.Int J Food Microbiol. 1998; 39: 237-238
- Probiotics: an overview of beneficial effects.Antonie van Leuwenhoek. 2002; 82: 279-289
- Probiotics in primary prevention of atopic disease: a randomized placebo-controlled trial.Lancet. 2001; 357: 1076-1079
- Supplementation with oral probiotic bacteria maintains cutaneous immune homeostasis after UV exposure.Eur J Dermatol. 2006; 16: 511-517
- Skin microflora.J Invest Dermatol. 1987; 88: 65s-72s
- A diversity profile of the human skin microbiota.Genome Res. 2008; 18: 1043-1050
- Substantial alterations of the cutaneous bacterial biota in psoriatic lesions.PLoS ONE. 2008; 3: e2719
- Immunomodulation by propionibacteria.Zentralblatt für Bakteriologie. 1990; 274: 289-298
- Propionibacterium acnes—friend or foe?.Rev Med Microbiol. 1994; 5: 163-173
- Propionibacterium acnes colonization in acne and nonacne.Dermatology. 1998; 196: 55-58
- Review: the human cutaneous microflora and factors controlling colonization.World J Microbiol Biotechnol. 2002; 18: 889-903
- Identification of secretory immunoglobulin A in human sweat and sweat glands.J Invest Dermatol. 1988; 90: 648-651
- Immunoglobulins coat microorganisms of skin surface: a comparative immunohistochemical and ultrastructural study of cutaneous and oral microbial symbionts.J Invest Dermatol. 1991; 96: 439-445
- Levels of antibody to Staphylococcus epidermidis in patients with acne vulgaris.Arch Dermatol. 1965; 92: 88-90
- Corynebacterium acnes. Presence of complement fixing antibodies to corynebacterium acnes in the sera of patients with acne vulgaris.Arch Dermatol. 1966; 93: 364-366
- Humoral immunity to Malassezia furfur serovars A, B, and C in patients with pityriasis versicolor, seborrehic dermatitis and controls.Exp Dermatol. 1994; 3: 227-233
- IgG subclasses specific to Staphylococcus epidermidis and Propionibacterium acnes in patients with acne vulgaris.Brit J Dermatol. 1997; 136: 730-733
- Delayed hypersensitivity to Propionibacterium acnes in patients with severe nodular acne and acne fulminans.Dermatology. 1994; 189: 344-349
- The effects of lipid extraction on the immunomodulatory activity of Malassezia species in vitro.Med Mycol. 2000; 38: 239-247
- Propionibacterium acnes and inflammation in acne: P acnes has T-cell mitogenic activity.Brit J Dermatol. 2002; 146: 202-206
- The skin barrier as an innate immune element.Semin Immunopathol. 2007; 29: 3-14
- Prebiotic cosmetics: an alternative to antibacterial products.IFSSC Mag. 2006; 9: 1-5
- Comparison of viable ell counts and fluorescence in situ hybridization using specific rRNA-based probes for the quantification of human feel bacteria.FEMS Microbiol Lett. 2000; 183: 125-129
- Cosmetics. What is their influence on the skin microflora?.Am J Clin Dermatol. 2002; 3: 445-449
- High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis.J Invest Dermatol. 2005; 125: 1163-1173
- Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain.Ped Res. 1992; 32: 141-144
- Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus.Lancet. 1994; 344: 1046-1049
- Efficacy of Lactobacillus preparation Biolactis powder in children with rotavirus enteritis.Jpn J Pediatr. 1994; 47: 2755-2762
- Bacteriotherapy with Lactobacillus reuteri in rotavirus gastroeneteritis.Ped Infect Dis J. 1997; 16: 1103-1107
- Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake.FEMS Immunol Med Microbiol. 1994; 10: 55-63
- Probiotics in the management of atopic eczema.Clin Exp Allergy. 2000; 30: 1605-1610
- Effect of probiotic Lactobacillus strains in children with atopic eczema.J Allergy Clin Immunol. 2003; 111: 389-395
- Probiotics in the treatment of atopic eczema/dermatitis syndromein infants: a double-blind placebo-controlled trial.Allergy. 2005; 60: 494-500
- Effects of prebiotics on atopic dermatitis: a randomized controlled trial.Arch Dis Child. 2005; 90: 892-897
- Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial.J Allerg Clin Immunol. 2007; 119: 1174-1180
- Lactobacillus GG effect in increasing IFN-gamma production in infants with cow's milk allergy.J Allerg Clin Immunol. 2004; 114: 131-136
- Immunomodulatory effects of probiotic bacteria DNA: Il-1 and IL-10 response in human peripheral blood mononucelar cells.FEMS Immunol Med Microbiol. 2003; 38: 165-172
- Clinical effects of probiortics are associated with increased interferon-gamma responses in very young children with atopic dermatitis.Clin Exp Allerg. 2005; 35: 1557-1564
- Lactobacillus casei reduces CD8+ T-cell-mediated skin inflammation.Eur J Immunol. 2004; 34: 2520-2528
- Supplementation with oral probiotic bacteria maintains cutaneous immune homeostasis after UV exposure.Eur J Dermatol. 2006; 16: 511-517
Bouilly D, Jeannes C, Duteil L, Pierard G, Picardi N, Manisier P, et al. Probiotic and carotenoids: an innovative nutritional approach to help skin against sun damage. J Dermatol Sci; in press.
- The consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function.Exp Dermatol. 2008; 7: 668-674
- Probiotics of the skin: a new area of potential application?.Lett Appl Microbiol. 2003; 36: 327-331
- Vitreoscilla filiformis biomass improves seborrheic dermatitis.JEADV. 2007; 17: 1468-1469
- Improvement of atoic dermatitzis skin symptoms by Vitreoscilla filiformis bacterial extract.EJD. 2006; 16: 380-384
Biography
Jean Krutmann is a professor of Dermatology and Environmental Medicine at the Heinrich-Heine-University, Düsseldorf, Germany. He holds appointments as an adjunct professor at CWRU and UAB, USA as well as Nagoya City University, Japan. He is the Director of IUF, an Institute of the Scientific Community Leibniz (WGL). He has received numerous scientific awards including C.E.R.I.E.S, has published more than 200 original papers and several monographs. He currently serves on the board of directors of the International Union of Photobiology, the European and the American Society of Photodermatology.
Article info
Publication history
Published online: July 12, 2010
Accepted:
January 20,
2009
Received:
January 7,
2009
Identification
Copyright
© 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
