Epithelial sheets made of cultured oral mucosal epithelial cells have been used to
treat various epithelial defects [
[1]
]. These epithelial sheets are derived from oral epithelial stem cells exhibiting high
proliferation potential. In the skin, research into the keratinocyte stem cell niche
has advanced remarkably. However, the oral mucosal stem cell niche is less well understood.
Thus, we investigated the density of label-retaining cells (LRC) in different areas
of oral mucosa to elucidate the localization of oral mucosal stem cells.Abbreviations:
BrdU (5-bromo-2′-deoxyuridine), LRC (label-retaining cells), PBS (phosphate-buffered saline)Keywords
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Article info
Publication history
Published online: July 12, 2010
Received:
November 13,
2008
Identification
Copyright
© 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
