Letter to the editor| Volume 55, ISSUE 2, P134-136, August 2009

Inhibition of protein kinase CK2 induces E2F1 nuclear export, formation of p21/E2F1 complexes and suppression of DNA synthesis in normal human epidermal keratinocytes

      Protein kinase CK2 (formerly termed “casein kinase II”) is an extremely conserved Ser/Thr kinase, which is ubiquitously distributed in eukaryotic cells. CK2 is quite unique enzyme, strongly distinguished from others protein kinases by particularly two properties—high constitutive activity and lack of an acute mechanism/s of regulation. The extreme pleiotropy (with list of over 300 substrates) is another of its characteristic [
      • Maggio F.
      • Pinna L.
      One-thousand-and-one substrates of protein kinase CK2?.
      ]. Despite of the gaps in understanding of precise molecular mechanisms the importance of CK2 in the context of signal transduction, gene expression and respectively in the cell regulation, including the maintenance of cell cycle is incontestable.
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