Atopic dermatitis (AD) is a common chronic inflammatory skin disease found in children and adults, and it is characterized by severe itching with typical skin lesions. Although most patients with AD have high concentrations of total and allergen-specific serum IgE levels, and positive skin prick test reactions to common environmental allergens, a subgroup of AD patients suffers from skin lesions without sensitization to aero- or food allergens. This analogy uses the term “intrinsic type of AD” (ADi) synonymously with “nonallergic AD”, “nonatopic eczema”, or “nonatopic AD” and as a counterpart to the term “extrinsic type of AD” (ADe). ADe has a Th2 cell mediated high serum IgE level and this condition is associated with IgE-mediated sensitization; this is seen in 70–80% of AD patients. As a counterpart to ADe, ADi is not involved with IgE-mediated sensitization and allergies, and ADi is seen in about 20–30% of AD patients.
Abbreviations:AD (atopic dermatitis), ADe (extrinsic type of AD), ADi (intrinsic type of AD), DEG (differentially expressed gene), PPI (protein–protein interactions), PSIMAP (protein structural interactome map), PEIMAP (protein experimental interactome map)
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Published online: July 12, 2010
Received: December 18, 2008
© 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.