Atopic dermatitis (AD) is a common chronic inflammatory skin disease found in children
and adults, and it is characterized by severe itching with typical skin lesions. Although
most patients with AD have high concentrations of total and allergen-specific serum
IgE levels, and positive skin prick test reactions to common environmental allergens,
a subgroup of AD patients suffers from skin lesions without sensitization to aero-
or food allergens. This analogy uses the term “intrinsic type of AD” (ADi) synonymously
with “nonallergic AD”, “nonatopic eczema”, or “nonatopic AD” and as a counterpart
to the term “extrinsic type of AD” (ADe). ADe has a Th2 cell mediated high serum IgE
level and this condition is associated with IgE-mediated sensitization; this is seen
in 70–80% of AD patients. As a counterpart to ADe, ADi is not involved with IgE-mediated
sensitization and allergies, and ADi is seen in about 20–30% of AD patients.
Abbreviations:
AD (atopic dermatitis), ADe (extrinsic type of AD), ADi (intrinsic type of AD), DEG (differentially expressed gene), PPI (protein–protein interactions), PSIMAP (protein structural interactome map), PEIMAP (protein experimental interactome map)Keywords
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Article info
Publication history
Published online: July 12, 2010
Received:
December 18,
2008
Identification
Copyright
© 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
