Abstract
Rosacea is a common and chronic inflammatory skin disease that affects over 10 million
Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are
all related by the presence of chronic facial skin inflammation. Until recently, the
pathophysiology of this disease has been poorly understood and limited to descriptions
of factors that exacerbate or improve this disorder. Recent molecular studies suggest
that an altered innate immune response is involved in the pathogenesis of the vascular
and inflammatory disease seen in patients with rosacea. These findings may help explain
the benefits of current treatments and suggest new therapeutic strategies helpful
for alleviating this disease. This article discusses the possible molecular mechanisms
for the pathogenesis of rosacea from current clinical observations and laboratory
research.
Keywords
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Article info
Publication history
Published online: July 12, 2010
Accepted:
April 29,
2009
Received in revised form:
April 27,
2009
Received:
February 28,
2009
Identification
Copyright
© 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
