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Letter to the Editor| Volume 55, ISSUE 2, P138-140, August 2009

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Analysis of variation in the IL7RA and IL2RA genes in atopic dermatitis

      Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex genetic background. It belongs to the group of atopic disorders that are characterized by a T helper (Th) type 2-dominated immune response. Recent evidence suggested that atopic diseases and autoimmune disorders (which are mainly Th1-driven) may not be mutually exclusive, but rather share certain risk factors that increase the development of either Th1- or Th2-immune responses to non-pathogenic antigens [
      • Simpson C.R.
      • Anderson W.J.
      • Helms P.J.
      • Taylor M.W.
      • Watson L.
      • Prescott G.J.
      • Godden D.J.
      • Barker R.N.
      Coincidence of immune-mediated diseases driven by Th1 and Th2 subsets suggests a common aetiology. A population-based study using computerized general practice data.
      ].

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