Letter to the Editor| Volume 55, ISSUE 3, P195-197, September 2009

The effect of proopiomelanocortin-derived peptides on the immune system of human hair follicles

      Proopiomelanocortin (POMC) is a prohormone produces various bioactive peptides via a series of enzymatic steps in a tissue-specific manner, including adrenocorticotropin (ACTH), α-melanocyte stimulating hormone (α-MSH), and β-endorphin. POMC is expressed not only in the pituitary gland, but also in a variety of non-pituitary organs, including the skin [
      • Millington G.W.
      Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors.
      ]. The functions of POMC-derived peptides in immunomodulation are still under investigation.


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