Psoriasis is a chronic, immuno-inflammatory disorder characterised by acanthosis with
disturbed keratinocyte differentiation. The stratum corneum (SC) in psoriatic lesional
skin is thick and histopathologically composed of parakeratotic cells. A changed lipid
pattern of the SC has been observed in lesional skin [
[1]
]. However, ceramide profiles in clinically normal psoriatic skin were comparable to
those of healthy skin [
[2]
]. As the clinical diagnosis of psoriasis is simple, most dermatologists tend to rely
on the traditional visual subjective assessments [
[3]
]. However, such assessments may still lack objectivity. Recently, commercially available
instruments have been used for the objective assessment of psoriasis. Poor hydration
state and barrier function in the involved areas were reported [
[4]
]. Different skin layers such as the SC and epidermis, as well as blood vessels, were
all distinguishable with optical coherence tomography (OCT) images [
[5]
]. The recently developed confocal Raman spectrometer has been applied to in vivo measurement of the depth profiles of SC components [
6
,
7
,
8
]. In the present study, we have evaluated characteristics of psoriatic skin by using
Raman spectroscopy as well as OCT.Keywords
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References
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- Comparison of the depth profiles of water and water-binding substances in the stratum corneum determined in vivo by Raman spectroscopy between the cheek and volar forearm skin: effects of age, seasonal changes, and artificial forced hydration.Br J Dermatol. 2008; 158: 251-260
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- Optical coherence tomography in contact dermatitis and psoriasis.Arch Dermatol Res. 2003; 295: 50-55
Article info
Publication history
Published online: July 12, 2010
Received:
May 12,
2009
Identification
Copyright
© 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
