In our previous studies we obtained evidence that the interleukin-19 (IL19) gene cluster and interleukin-20 receptor alpha (IL20RA) gene may represent susceptibility regions for psoriasis [
1
,
2
,
3
]. The aim of the present study was to scan an additional set of single nucleotide
polymorphisms (SNPs) in the chromosomal region 6q22-24, which contains IL20RA, the genes for interleukin-22 receptor alpha 2 (IL22RA2) and interferon-gamma receptor 1 (IFNGR1) for association with psoriasis.Keywords
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References
- Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis.Genes Immun. 2004; 5: 662-667
- Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasis.Genes Immun. 2005; 6: 407-415
- Association analysis of IL20RA and IL20RB genes in psoriasis.Genes Immun. 2008; 9: 445-451
- Assessment of two flexible and compatible SNP genotyping platforms: TaqMan SNP Genotyping Assays and the SNPlex Genotyping System.Mutat Res. 2005; 573: 111-135
- Haploview: analysis and visualization of LD and haplotype maps.Bioinformatics. 2005; 21: 263-265
- IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.J Exp Med. 2006; 203: 2577-2587
- Interleukin-20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model.Br J Dermatol. 2008;
- Interleukin-20 as a target in psoriasis treatment.Ann NY Acad Sci. 2007; 1110: 368-381
- The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.J Immunol. 2007; 178: 2229-2240
- Detection of IL-20 and its receptors on psoriatic skin.Clin Immunol. 2005; 117: 65-72
Article info
Publication history
Published online: July 12, 2010
Received:
July 10,
2009
Identification
Copyright
© 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
