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Down regulation of CD147 boosts the premature senescence in human skin fibroblasts by destroying the redox balance and inhibiting klotho

  • Author Footnotes
    1 These authors contributed equally to this work.
    Hongfu Xie
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Dermatology, XiangYa Hospital, Central South University, 87 XiangYa Road, Changsha, Hunan, 410008, China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Leishan Liu
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Dermatology, XiangYa Hospital, Central South University, 87 XiangYa Road, Changsha, Hunan, 410008, China
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  • Wei Shi
    Affiliations
    Department of Dermatology, XiangYa Hospital, Central South University, 87 XiangYa Road, Changsha, Hunan, 410008, China
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  • Xiao Xiao
    Affiliations
    Department of Dermatology, XiangYa Hospital, Central South University, 87 XiangYa Road, Changsha, Hunan, 410008, China
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  • Liming Tian
    Affiliations
    Department of Dermatology, XiangYa Hospital, Central South University, 87 XiangYa Road, Changsha, Hunan, 410008, China
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  • Dan Jian
    Affiliations
    Department of Dermatology, XiangYa Hospital, Central South University, 87 XiangYa Road, Changsha, Hunan, 410008, China
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  • Xiang Chen
    Affiliations
    Department of Dermatology, XiangYa Hospital, Central South University, 87 XiangYa Road, Changsha, Hunan, 410008, China
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  • Ji Li
    Correspondence
    Corresponding author at: Department of Dermatology, XiangYa Hospital, Central South University, 87 XiangYa Road, Changsha, Hunan, 410008, China. Tel.: +86 731 84327472; fax: +86 731 89753406.
    Affiliations
    Department of Dermatology, XiangYa Hospital, Central South University, 87 XiangYa Road, Changsha, Hunan, 410008, China
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.
      The free radical theory of senescence holds the molecular basis of senescence is derived from the accumulation of oxidative damage resulting from excess reactive oxygen species (ROS) in cells [
      • Woo D.K.
      • Shadel G.S.
      Mitochondrial stress signals revise an old aging theory.
      ]. Hydrogen peroxide (H2O2) is a major contributor to oxidative stress and has been shown to induce senescence in normal human skin fibroblasts (NHSFs) [
      • Tian L.M.
      • Xie H.F.
      • Xiao X.
      • Yang T.
      • Hu Y.H.
      • Wang W.Z.
      • et al.
      Study on the roles of β-catenin in hydrogen peroxide-induced senescence in human skin fibroblasts.
      ]. However, the exact molecular mechanism of cellular senescence is still unknown.
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