In normal human skin, the basement membrane (BM) lies between the epidermis and dermis, connecting the two compartments tightly and keeping them from direct contact. During skin wound healing, fibroblasts from adjacent intact dermis are activated and migrate to fibrin clots to form granulation tissue, onto which activated keratinocytes at the wound margin migrate, stratify, and differentiate to form a new integument; however, a well-developed BM is not observed until a few months later [
]. During this period, homeostasis between the epidermal and dermal compartments is interrupted and abnormal epidermal–dermal events can ensue.
- Bergman R.
- David R.
- Ramon Y.
- Ramon M.
- Kerner H.
- Kilim S.
- et al.
Delayed postburn blisters: an immunohistochemical and ultrastructural study.
J Cutan Pathol. 1997; 24: 429-433
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- Delayed postburn blisters: an immunohistochemical and ultrastructural study.J Cutan Pathol. 1997; 24: 429-433
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Published online: February 03, 2012
Received: February 16, 2011
☆This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and by Health and Labour Sciences Research Grants (Research on Intractable Diseases) from the Ministry of Health, Labour and Welfare of Japan.
© 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.