In normal human skin, the basement membrane (BM) lies between the epidermis and dermis,
connecting the two compartments tightly and keeping them from direct contact. During
skin wound healing, fibroblasts from adjacent intact dermis are activated and migrate
to fibrin clots to form granulation tissue, onto which activated keratinocytes at
the wound margin migrate, stratify, and differentiate to form a new integument; however,
a well-developed BM is not observed until a few months later [
[1]
]. During this period, homeostasis between the epidermal and dermal compartments is
interrupted and abnormal epidermal–dermal events can ensue.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Published online: February 03, 2012
Received:
February 16,
2011
Footnotes
☆This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and by Health and Labour Sciences Research Grants (Research on Intractable Diseases) from the Ministry of Health, Labour and Welfare of Japan.
Identification
Copyright
© 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
