Beside ultraviolet radiation (UV), the skin is exposed to other stressors such as
cigarette smoke (CS) and ozone (O3). O3 is not a radical species per se and its toxic effect is mediated by the production
of a cascade of bioactive molecules (i.e. hydroxyl radical and aldehydes). CS contains
more than 4300 different chemicals, most of which are classified as carcinogens for
several tissues including the skin. Both, O3 and CS have been shown to induce oxidative stress and to deprive tissues of their
antioxidants defense [
[1]
]. There is increasing evidence that the susceptibility to air toxicants effect varies
from one individual to another and those who suffer more from exposure to air pollution
are the elderly [
[2]
]. We have previously documented that O3 and CS modulate MMP's activity and the responses are affected by age [
[3]
]. To further explore the skin's response to oxidants, young (8-week-old) and aged
(18-month old) SKH1 mice were exposed to O3 (6 h/day at 0.25 ppm) or CS (6 h/day) for 4 days as previously described [
[3]
]. Oxidative stress and inflammation markers were analyzed by Western blot in skin
tissue homogenate. All statistical analyses were performed using one-way analysis
of variance (ANOVA).Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Dermatological ScienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- In vivo ozone exposure induces antioxidant/stress-related responses in murine lung and skin.Free Radic Biol Med. 2004; 36: 673-681
- The elderly as a sensitive population in environmental exposures: making the case.Rev Environ Contam Toxicol. 2010; 207: 95-157
- Cutaneous MMPs are differently modulated by environmental stressors in old and young mice.Toxicol Lett. 2007; 173: 73-79
- Ozone exposure activates oxidative stress responses in murine skin.Toxicology. 2002; 179: 163-170
- Age related changes of epidermal cell kinetics in the hairless mice.Virchows Arch B Cell Pathol Incl Mol Pathol. 1984; 46: 135-143
- Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice.J Biol Chem. 2010; 285: 1153-1165
- The p66shc adaptor protein controls oxidative stress response and life span in mammals.Nature. 1999; 402: 309-313
- Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the Bacopa monniera extract: potential implication in Alzheimer's disease.J Alzheimers Dis. 2010; 21: 229-247
- Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.Diabetologia. 2007; 50: 1997-2007
- Ozone potentiates vitamin E depletion by ultraviolet radiation in the murine stratum corneum.FEBS Lett. 2000; 466: 165-168
Article info
Publication history
Published online: January 25, 2012
Received:
April 18,
2011
Identification
Copyright
© 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
