Behçet's disease (BD) is a systemic chronic inflammatory disorder characterized by
recurrent oral aphtha, genital ulcers, uveitis, and skin lesions. The etiology and
pathogenesis of BD are unknown; however, many studies show a predominant T helper
(TH1)-mediated immune response in BD [
[1]
]. Recently, a novel cell surface protein, T cell immunoglobulin and mucin domain (TIM),
was identified [
[2]
]. Among three genes (TIM-1, TIM-3 and TIM-4) in humans, TIM-3 was found to be specifically expressed by differentiated TH1 cells [
[3]
]. Later TIM-3 expression was demonstrated in other cell populations such as Th17,
CD8+ cells, NK cells, NCT cells and monocytes [
4
,
5
]. The role of Tim-3 in autoimmune diseases and inflammatory diseases has been accumulated. In vivo blockade of Tim-3 enhanced the onset in an adoptive transfer model of autoimmune
diabetes [
[6]
]. In multiple sclerosis, preferential TIM-3 expression on TH1 cells [
[7]
] is reported. Considering that TH1 immune responses play an important role in the pathogenesis of BD, we wanted to
examine the expression of TIM-3 in BD patients and to determine whether TIM-3 expression
is correlated with disease activity.- Khademi M.
- Illés Z.
- Gielen A.W.
- Marta M.
- Takazawa N.
- Baecher-Allan C.
- et al.
T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are
differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived
mononuclear cells in multiple sclerosis.
J Immunol. 2004; 172: 7169-7176
Keywords
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References
- Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease.Clin Exp Immunol. 2005; 139: 371-378
- The TIM gene family: emerging roles in immunity and disease.Nat Rev Immunol. 2003; 3: 454-462
- Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.Nature. 2002; 415: 536-541
- Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17.J Leukoc Biol. 2007; 81: 1258-1268
- Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity.Clin Immunol. 2010; 137: 288-295
- Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.Nat Immunol. 2003; 4: 1093-1101
- T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis.J Immunol. 2004; 172: 7169-7176
- Lack of TIM-3 immunoregulation in multiple sclerosis.J Immunol. 2008; 180: 4409-4414
- TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.Eur J Immunol. 2009; 39: 2492-2501
- CD4(+) CD25(+) regulatory T cells ameliorate Behcet's disease-like symptoms in a mouse model.Cytotherapy. 2011; https://doi.org/10.3109/14653249.2011.571245
Article info
Publication history
Published online: February 16, 2012
Received:
June 23,
2011
Identification
Copyright
© 2012 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
