EPR (electron paramagnetic resonance) is useful for elucidating structural aspects
of stratum corneum (SC) [
1
,
2
,
3
]. Non-invasive spectroscopic characterization of the outermost layer of the SC is
an important subject in dermatology and cosmetology. The SC, a heterogeneous structure
composed of corneocytes embedded in the intercellular lamellar lipid bilayer, acts
as the main epidermal barrier against chemicals, oxidative stress, and other invasive
environmental factors, as well as regulating TEWL (transepidermal water loss) to prevent
dehydration of viable cells underneath the SC. The measurement of TEWL is the most
common method to estimate the state of the skin. However, the TEWL does not provide
structural information about the lipid in the SC.Keywords
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References
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- Depth dependence of stratum corneum lipid ordering: a slow-tumbling simulation for electron paramagnetic resonance.J Invest Dermatol. 2007; 127: 895-899
- Electron paramagnetic resonance investigation of stratum corneum lipid structure.Lipids. 2010; 45: 91-96
- Nonlinear-least-squares analysis of slow-motion EPR spectra in one and two dimensions using a modified Levenberg–Marquardt algorithm.J Magn Reson Ser A. 1996; 120: 155-189
- ESR studies of stearic acid binding to bovine serum albumin.Biochim Biophys Acta. 1990; 1036: 228-236
- Psoriatic architecture constructed by epidermal remodeling.J Dermatol Sci. 2004; 35: 93-99
- Relation between the expression levels of the POU transcription factors Skn-1a and Skn-1n and keratinocyte differentiation.J Dermatol Sci. 2010; 60: 203-205
- TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier.J Invest Dermatol. 2011; 131: 1272-1279
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Article info
Publication history
Published online: February 06, 2012
Received:
November 1,
2011
Identification
Copyright
© 2012 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
