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Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update

Published:November 19, 2012DOI:https://doi.org/10.1016/j.jdermsci.2012.10.001

      Abstract

      Human hair disorders comprise a number of different types of alopecia, atrichia, hypotrichosis, distinct hair shaft disorders as well as hirsutism and hypertrichosis. Their causes vary from genodermatoses (e.g. hypotrichoses) via immunological disorders (e.g. alopecia areata, autoimmune cicatrical alopecias) to hormone-dependent abnormalities (e.g. androgenetic alopecia). A large number of spontaneous mouse mutants and genetically engineered mice develop abnormalities in hair follicle morphogenesis, cycling, and/or hair shaft formation, whose analysis has proven invaluable to define the molecular regulation of hair growth, ranging from hair follicle development, and cycling to hair shaft formation and stem cell biology. Also, the accumulating reports on hair phenotypes of mouse strains provide important pointers to better understand the molecular mechanisms underlying human hair growth disorders. Since numerous new mouse mutants with a hair phenotype have been reported since the publication of our earlier review on this matter a decade ago, we present here an updated, tabulated mini-review. The updated annotated tables list a wide selection of mouse mutants with hair growth abnormalities, classified into four categories: Mutations that affect hair follicle (1) morphogenesis, (2) cycling, (3) structure, and (4) mutations that induce extrafollicular events (for example immune system defects) resulting in secondary hair growth abnormalities. This synthesis is intended to provide a useful source of reference when studying the molecular controls of hair follicle growth and differentiation, and whenever the hair phenotypes of a newly generated mouse mutant need to be compared with existing ones.

      Abbreviations:

      ENU (ethyl-nitrosourea induced chemical mutagenesis), GEMs (genetically engineered mice), HF (hair follicle), Rad (radiation induced), S (spontaneous mutation), Tg (transgenic), TGF (transforming growth factor), Tm (targeted mutation)

      Keywords

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      Biography

      Motonobu Nakamura (MD, PhD) is Professor at Department of Dermatology in University of Occupational and Environmental Health, Japan. He graduated from Kyoto University, Japan and received his MD degree in 1991. He received his PhD in 1997 at Kyoto University. In 2000–2002, he served as Visiting Researcher under Prof. Ralf Paus at Department of Dermatology, University Medical Center Hamburg-Eppendorf, Germany. He moved to University of Occupational and Environmental Health as the Assistant Professor in 2008 and became Professor in 2012. His research interest includes pathomechanisms of alopecia.