Proopiomelanocortin is a precursor peptide that gives rise to several neuropeptides including adrenocorticotrophic hormone (ACTH) and beta-endorphin. POMC derived peptides have been shown to be synthesized in human epidermis where they modulate numerous skin functions. Because we previously observed that melanocortin receptor-2 and micro-opioid receptor 1, the respective receptors for ACTH and beta-endorphin decreased with aging in human epidermis, we have selected an active ingredient (INCI name: Achillea millefolium extract) able to upregulate receptor expressions. The aim of the present work was to first evaluate the effect of Achillea millefolium extract on the expression pattern of various epidermal differentiation markers ex vivo in normal human skin biopsies using quantitative image analysis and second to evaluate its capacity to rejuvenate the appearance of skin surface in vivo.
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Published online: December 20, 2012
© 2012 Published by Elsevier Inc.
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- JSID AbstractsJournal of Dermatological ScienceVol. 69Issue 2