Proopiomelanocortin is a precursor peptide that gives rise to several neuropeptides
including adrenocorticotrophic hormone (ACTH) and beta-endorphin. POMC derived peptides
have been shown to be synthesized in human epidermis where they modulate numerous
skin functions. Because we previously observed that melanocortin receptor-2 and micro-opioid
receptor 1, the respective receptors for ACTH and beta-endorphin decreased with aging
in human epidermis, we have selected an active ingredient (INCI name: Achillea millefolium
extract) able to upregulate receptor expressions. The aim of the present work was
to first evaluate the effect of Achillea millefolium extract on the expression pattern
of various epidermal differentiation markers ex vivo in normal human skin biopsies
using quantitative image analysis and second to evaluate its capacity to rejuvenate
the appearance of skin surface in vivo.
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Publication history
Published online: December 20, 2012
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© 2012 Published by Elsevier Inc.
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- JSID AbstractsJournal of Dermatological ScienceVol. 69Issue 2
