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Emerging role for the killer-cell immunoglobulin-like receptors genotype, in the susceptibility of skin diseases

      Abstract

      NK cells are a major group of immune cells responsible for the phenomenon of natural, innate cytotoxicity. One of the better studied receptors of human NK cells are killer cell immunoglobulin-like receptors (KIR) responsible for checking the presence of MHC class I molecules, which serve as their ligands. Although previously treated as specific for NK cells, nowadays these receptors are known to also occur on T cells. Genetics of KIR molecules is very complicated, what create a great variability of haplotypes in various populations world-wide. In addition, some KIR are known to recognize HLA-C (epitopes C1 or C2), HLA-B (Bw4) or HLA-A (A3 and/or A11) molecules. Therefore, this makes a huge diversity of reactions among individuals, depending on the presence or absence of given KIR and their ligands, hence differential susceptibility to several diseases, including various dermatoses. This paper underlines the important role of both KIR genotypes and HLA class I genes with reference to the various skin diseases.

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      Biography

      Lukasz Matusiak, MD, PhD – Dermatologist and Venereologist, Adjunct Professor of Department of Dermatology, Venereology and Allergology (Wroclaw Medical University, Poland), the member of the Polish Dermatological Society, the member of the European Academy of Dermatology and Venereology, the member of the European Society for Dermatological Research and the International Society of Dermatology. As an author and co-author he has published nearly 50 scientific publications, including approximately 30 original papers and case studies, 8 book's chapters and 1 book (on psoriatic arthritis). He participated in many national and international scientific conferences (including Spain, Italy, Portugal, Switzerland, Germany, South Korea, USA, etc.), where he gave more than 50 lectures. Since 2008, he is a translator of Polish edition of “Journal Watch Dermatology” and reviewer of international journals placed on the so-called Philadelphia List (“Acta Dermato-Venereologica”, “Journal of the European Academy of Dermatology and Venereology”, “Dermatologic Surgery”, etc.). In the same year he defended his PhD dissertation. The main fields of interests: hidradenitis suppurativa, dermatological surgery, and the most recently – immunology of inflammatory skin diseases.