Non-segmental vitiligo (NSV) is an acquired chronic pigmentation disorder characterized
by depigmented macules of various sizes with tendency toward symmetrical distribution
[
1
,
2
]. Despite many studies performed on vitiligo skin, the exact pathogenesis of this
dermatosis is still to be clarified. Recently, it has been suggested that the major
and possible primary predisposing factor in vitiligo development could be a defective
adhesion of melanocytes and that mechanical trauma and various chemical stressors
could represent the main precipitating events [
3
,
4
].To read this article in full you will need to make a payment
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References
- Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up.J Am Acad Dermatol. 2011; 65: 473-491
- Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference.Pigment Cell Melanoma Res. 2012; 25: E1-E13
- The melanocytorrhagic hypothesis of vitiligo tested on pigmented, stressed, reconstructed epidermis.Pigment Cell Melanoma Res. 2007; 20: 385-393
- Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo.Br J Dermatol. 2003; 148: 95-101
- CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1.J Cell Biol. 2006; 175: 563-569
- Role of integrins in melanocyte attachment and dendricity.J Cell Sci. 1994; 107: 2739-2748
- Active detachment involves inhibition of cell-matrix contacts of malignant melanoma cells by secretion of melanoma inhibitory activity.Lab Invest. 2003; 83: 1583-1594
- Regulation of integrin activity by MIA.J Biol Chem. 2006; 281: 11669-11677
Article info
Publication history
Published online: May 09, 2013
Received:
October 19,
2012
Identification
Copyright
© 2013 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
