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Role of alpha5beta1 integrin and MIA (melanoma inhibitory activity) in the pathogenesis of vitiligo

      Non-segmental vitiligo (NSV) is an acquired chronic pigmentation disorder characterized by depigmented macules of various sizes with tendency toward symmetrical distribution [
      • Alikhan A.
      • Felsten L.M.
      • Daly M.
      • Petronic-Rosic V.
      Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up.
      ,
      • Ezzedine K.
      • Lim H.W.
      • Suzuki T.
      • Katayama I.
      • Hamzavi I.
      • Lan C.C.
      • et al.
      Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference.
      ]. Despite many studies performed on vitiligo skin, the exact pathogenesis of this dermatosis is still to be clarified. Recently, it has been suggested that the major and possible primary predisposing factor in vitiligo development could be a defective adhesion of melanocytes and that mechanical trauma and various chemical stressors could represent the main precipitating events [
      • Cario-Andre’ M.
      • Pain C.
      • Gauthier Y.
      • Taïeb A.
      The melanocytorrhagic hypothesis of vitiligo tested on pigmented, stressed, reconstructed epidermis.
      ,
      • Gauthier Y.
      • Cario-Andre M.
      • Lepreux S.
      • Pain C.
      • Taieb A.
      Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo.
      ].
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      References

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