Krüppel-like factor 10 (KLF10), also known as TGF-β-inducible early gene-1 (TIEG1),
was initially identified in normal human fetal osteoblasts following TGF-β treatment
and contains three zinc finger domains at the N-terminal end and several Src homology-3
(SH3) domains at the C-terminal end [
[1]
]. KLF10 mimics TGF-β activity through the downstream transcription factor Smad [
[1]
]. To elucidate the functions of KLF10, KLF10-deficient (KLF10−/−) mice were produced [
2
,
3
]. In two step skin tumorigenesis model, KLF10−/− mice revealed that KLF10 plays a role in skin tumor formation and acts as a tumor
suppressor [
[3]
].Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Dermatological ScienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Nucleic Acids Res. 1995; 23: 4907-4912
- J Cell Biochem. 2007; 102: 539-548
- Biochem Biophys Res Commun. 2012; 419: 388-394
- J Biol Chem. 2007; 282: 13769-13779
- Proc Natl Acad Sci USA. 2006; 103: 6653-6658
- J Biol Chem. 2009; 284: 24914-24924
- Clin Exp Allergy. 1999; 22: 241-250
- Toxicology. 2006; 219: 113-123
Article info
Publication history
Published online: May 28, 2013
Received:
January 14,
2013
Identification
Copyright
© 2013 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
