Vitiligo is an acquired skin disorder characterized by the loss of skin pigmentation. Although the dysfunction of melanocytes occurs in vitiligo, its pathogenesis still remains unknown. Autoimmunity to melanocytes or their specific organelles has been proposed to be involved in the pathogenesis of vitiligo. Alternatively, impairment in the melanogenic cytokine network between melanocytes and epidermal keratinocytes has also been regarded as a possible cause of vitiligo [
- Moretti S.
- Spallanzani A.
- Amato L.
- Hautmann G.
- Gallerani I.
- Fabiani M.
- et al.
New insight into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions.
Pigment Cell Res. 2002; 15: 87-92
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- New insight into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions.Pigment Cell Res. 2002; 15: 87-92
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Published online: July 01, 2013
Received: October 19, 2012
© 2013 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.