Highlights
- •Pollution-induced skin damage is a global problem with particular relevance in China and India.
- •Ambient particulate matter exposure contributes to premature skin aging.
- •Ozone depletes antioxidants from skin.
- •Air pollution exerts detrimental effects on healthy and diseased skin.
- •The arylhydrocarbon receptor is key in mediating air pollution-induced skin damage.
- •Individuals with sensitive skin may represent a susceptible subgroup.
- •Specific cosmetic products are required to protect skin from air pollution-induced damage.
Abstract
Abbreviations:
AhR (arylhydrocarbon receptor), PM (particulate matter), PAN (peroxy acetyl nitrates), MDA (malondialdehyde), MMP (matrix metalloproteinase), PAH (polyaromatic hydrocarbons), UV (ultraviolet radiation), VOC (volatile organic compounds)Keywords
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Dermatological ScienceReferences
WHO. Burden of Disease from Household Air Pollution for 2012. www.who.int/phe/health_topics/outdoorair/databases/FINAL_HAP_AAP_BoD_24March2014.pdf (accessed 25.07.14).
- Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association.Circulation. 2010; 121: 2331-2378
- Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project.Lancet. 2014; 383: 785-795
- Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE).Lancet Oncol. 2013; 14: 813-822
- Sensory, clinical and physiological factors in sensitive skin.Contact Dermat. 2006; 55: 1-14
- Sensitive skin in Europe 2009.J Eur Acad Dermatol Venereol. 2009; 23: 376-381
- Sensitive skin in the American population prevalence, clinical data, role of the dermatologist.Int J Dermatol. 2011; 50: 961-967
- Self-declared sensitive skin in China: a community-based study in three top metropolises.Eur Acad Dermatol Venereol. 2013; 27: 370-375
WHO's Ambient Air Pollution Database – Update 2014. www.who.int/phe/health_topics/outdoorair/databases/AAP_database_results2014.pdf (accessed 25.07.14).
- Assessment of metals pollution and health risk in dust from nursery schools in Xi’an, China.Environ Res. 2014; 128: 27-34
- Asian sand dust aggravates allergic rhinitis in guinea pigs induced by Japanese cedar pollen.Inhal Toxicol. 2009; 21: 985-993
- Global estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth: development and application.Environ Health Perspect. 2010; 118: 847-855
University. BMICC. Global Annual Average PM2.5 Grids from MODIS and MISR Aerosol Optical Depth: Asia 2010. http://sedac.ciesin.columbia.edu/data/set/sdei-global-annual-avg-pm2-5-2001-2010/maps (accessed 25.07.14).
- A global single-sensor analysis of 2002–2011 tropospheric nitrogen dioxide trends observed from space.J Geophys Res. 2012; 117: D16309https://doi.org/10.1029/2012JD017571
- Confounding and effect modification in the short-term effects of ambient particles on total mortality: results from 29 European cities within the APHEA2 Project.Epidemiology. 2001; 12: 521-531
- The national morbidity, mortality and air pollution study part II: Morbidity and mortality from air polluiton in the United States.in: Research Report from Health Effects Institute. 2002 (www.cabq.gov/airquality/documents/pdf/samet2.pdf (accessed 25.07.14))
- Relationship between ambient fine particles and ventricular repolarization changes and heart rate variability of elderly people with heart disease in Beijing, China.Biomed Environ Sci. 2013; 26: 629-637
- The association between fine particulate air pollution and hospital emergency room visits for cardiovascular diseases in Beijing, China.Sci Total Environ. 2009; 407: 4826-4830
- Effects of airborne metals on lung function in inner Mongolian schoolchildren.J Occup Environ Med. 2013; 55: 80-86
- The acute effects of fine particles on respiratory mortality and morbidity in Beijing, 2004–2009.Int Environ Sci Pollut Res. 2013; 20: 6433-6444
- The outdoor air pollution and brain health workshop.Neurotoxicology. 2012; 33: 972-984
- Airborne particle exposure and extrinsic skin aging.J Invest Dermatol. 2010; 130: 2719-2726
- Indoor air pollution from cooking with coal or firewood accelerates skin aging in northern Chinese women.J Invest Dermatol. 2014; 134 ([abstract]): S51
- Ethnic differences and environmental factors in skin aging.J Invest Dermatol. 2014; 134 ([abstract]): S52
- Symptoms of atopic dermatitis are influenced by outdoor pollution.J Allergy Clin Immunol. 2013; 132: 495-497
- Are the short-term effects of air pollution restricted to cardiorespiratory diseases.Am J Epidemiol. 2009; 169: 1201-1208
- Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas.J Dermatol Sci. 2009; 56: 99-105
- Ambient ozone as a risk factor for skin disorders.Br J Dermatol. 2011; 165: 99-228
- COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo.Toxicol Lett. 2008; 176: 178-187
- Role of inflammation in cardiopulmonary health effects of PM.Toxicol Appl Pharmacol. 2005; 207: 483-488
- Ligthening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B tradiation.Proc Natl Acad Sci USA. 2007; 104: 8851-8856
- The aryl hydrocarbon receptor mediates UVB radiation-induced skin tanning.J Invest Dermatol. 2011; 131: 203-210
- Asian dust storm particles induce a broad toxicological transcriptional programin human epidermal keratinocytes.Toxicol Lett. 2011; 200: 92-99
- Ozone depletes tocopherols and tocotrienols topically applied to murine skin.FEBS Lett. 1997; 401: 167-170
- Vitamin C, uric acid and glutathione gradients in murine stratum corneum and their susceptability to ozone exposure.J Invest Dermatol. 1999; 113: 1128-1132
- Cutaneous responses to environmental stressors.Ann NY Acad Sci. 2012; 1271: 5-81
- Cutaneous MMPs are differently modulated by environmental stressors in old and young mice.Toxicol Lett. 2007; 173: 73-79
- Aryl hydrocarbon receptor is an ozone sensor in human skin.J Invest Dermatol. 2009; 129: 2396-2403
- Ozone exposure activates oxidative stress responses in murine skin.Toxicology. 2002; 179: 163-170
- Mechanisms of radical formation from reactions of ozone with target molecules in the lung.Free Radic Biol Med. 1994; 17: 451-465
- Sensitive skin: closing in on a physiological cause.Contact Dermat. 2010; 62: 137-149
- Epidemiological survey on sensitive skin of college students in Beijing.in: Proceedings of the 2nd congress of Chinese fMedical Women's Association. 2013: 158-164
- Epidemiolgical study of sensitive skin in Shanghai.J Clin Dermatol. 2011; 40: 403-406
- Sensory, clinical and physiological factors in sensitive skin: a review.Contact Dermat. 2006; 55: 1-14
- Ethnic variations in facial skin neurosensitivity assessed by capsaicin detection thresholds.Contact Dermat. 2009; 61: 325-331
- Synergistic damage by UVA radiation and pollutants.Toxicol Ind Health. 2009; 25: 219-224
- The new aryl hydrocarbon receptor antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one protects against UVB-induced signal transduction.J Invest Dermatol. 2014; 134: 556-559
Biography
