Abstract
Wound healing is a well-orchestrated process, where numerous factors are activated
or inhibited in a sequence of steps. Immediately after the infliction of damage, the
repair of wound stars. The initial step is an inflammatory change with activation
of innate immunity, which is followed by proliferation phase, including fibroplasia,
angiogenesis and re-epithelialization. Pathological impairment of wound healing process
may lead to persistent ulceration as seen in diabetic patients. Various signaling
pathways are involved in wound healing. TGFβ/Smad pathway is a representative and
well known to participate in fibroplasia, however, its comprehensive effect on wound
healing is controversial. Experimental and clinical remedies have been being tried
to promote wound healing. Advancement of cell engineering allows us to use stem cells
and living skin equivalents.
Keywords
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Biography
Akira Kasuya received the MD from Niigata University, Japan, in 2006. He moved to Hamamatsu University School of Medicine. He was assigned as an Assistant Professor at Department of Dermatology in 2011. His interests are wound healing and immunology.
Article info
Publication history
Published online: November 11, 2014
Accepted:
November 10,
2014
Received in revised form:
November 10,
2014
Received:
November 7,
2014
Identification
Copyright
© 2014 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
