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Real-time imaging of interaction between macrophages and lymphatic vessels in an in vitro model to study inflammatory resolution

Published:December 04, 2014DOI:https://doi.org/10.1016/j.jdermsci.2014.11.010
      The inflammatory response is a defense against harmful microbes, physical trauma and other exogenous threats. However, persistent inflammation (failure of resolution) can damage tissues and lead to various diseases [
      • Nathan C.
      • Ding A.
      Nonresolving inflammation.
      ]. Inflammation is characterized by rapid recruitment of blood granulocytes, typically neutrophils, followed by the influx of monocytes, which mature into inflammatory macrophages. Then, neutrophil recruitment ceases and programmed death by apoptosis is initiated. Apoptotic neutrophils undergo phagocytosis by macrophages, which are subsequently cleared by removal from the inflamed sites through lymphatic vessels [
      • Serhan C.N.
      • Savill J.
      Resolution of inflammation: the beginning programs the end.
      ].
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