The inflammatory response is a defense against harmful microbes, physical trauma and
other exogenous threats. However, persistent inflammation (failure of resolution)
can damage tissues and lead to various diseases [
[1]
]. Inflammation is characterized by rapid recruitment of blood granulocytes, typically
neutrophils, followed by the influx of monocytes, which mature into inflammatory macrophages.
Then, neutrophil recruitment ceases and programmed death by apoptosis is initiated.
Apoptotic neutrophils undergo phagocytosis by macrophages, which are subsequently
cleared by removal from the inflamed sites through lymphatic vessels [
[2]
].To read this article in full you will need to make a payment
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References
- Nonresolving inflammation.Cell. 2010; 140: 871-882
- Resolution of inflammation: the beginning programs the end.Nat Immunol. 2005; 6: 1191-1197
- The cutaneous vascular system in chronic skin inflammation.J Investig Dermatol Symp Proc. 2011; 15: 24-32
- Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis.J Invest Dermatol. 2009; 129: 1292-1298
- Dendritic-cell trafficking to lymph nodes through lymphatic vessels.Nat Rev Immunol. 2005; 5: 617-628
- CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19.Eur J Immunol. 2010; 40: 1266-1271
- Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression.J Immunol. 2006; 177: 7303-7311
- Age-associated chronic diseases require age-old medicine: role of chronic inflammation.Prev Med. 2012; 54: S29-S37
- Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration.Int Immunol. 2010; 22: 839-849
Article info
Publication history
Published online: December 04, 2014
Received:
April 3,
2014
Identification
Copyright
© 2014 Japanese Society for Investigative Dermatology. Published by Elsevier Inc. All rights reserved.
