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Sandalwood oil is an essential oil obtained from the steam distillation from the heartwood
of the sandalwood (Santalum album) tree. Sandalwood oil is used in perfumes, cosmetics,
and medicines. Recently, sandalwood oil was reported to act suppressing inflammatory
reaction, and promoting apoptosis and cell proliferation. In this study, we found
that sandalwood oil induced Epithelial-Mesenchymal Transition (EMT) in keratinocytes,
however mechanism of action of EMT is still remained unclear. Firstly, we investigated
EMT-related gene expression at 4, 8 h after sandalwood oil treated human normal epidermal keratinocytes (NHEK) by real-time
PCR analysis. The expression of EMT-related transcription factors (snail, twist) and
mesenchymal factor (vimentin) were enhanced by sandalwood oil in cultured keratinocytes.
Secondly, we assessed wound scratch assay with NHEK in sandalwood oil or control.
Sandalwood oil stimulation promoted epidermal wound healing compared with control.
In addition, we performed cutaneous wound healing assay using 8-mm round wounds on
the backs and applied sandalwood oils or vehicle control. Taken together, our results
suggest that sandalwood oil enhanced EMT and promoted wound healing in keratinocytes.
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