The presence of Glyceraldehyde-derived AGEs in the skin

      Advanced glycation endproducts (AGEs), which are linked to both aging and hyperglycemia, are generated via Maillard reaction between aldehyde group and amino group in proteins, evoking protein degeneration and inflammation. Above all, recent reports propose that glyceraldehyde-derived AGEs (Glycer-AGEs) which is produced in process of glycolysis and intracellular metabolism, plays an important role in pathogenesis of lifestyle-related diseases like hyperglycemia. Thus, it is expected the possibility that Glycer-AGEs is highly affected to intracellular metabolism. However, the presence of Glycer-AGEs in the skin has not been elucidated, although 95% of the epidermis consists of keratinocytes.
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