Hair dyes are frequently used to meet cosmetic needs. With their increased usage, many patients visit dermatologists complaining of the adverse event of hair dye–induced hair loss, which is induced by oxidative stress caused by the hydrogen peroxide (H2O2) in the dye [
]. The oxidative stress caused by H2O2 is considered cytotoxic in animals, plants, and cultured cells. Despite its cytotoxic effects, H2O2 is required to modulate inter- and intracellular signaling pathways, including the β-catenin pathway [
- Seo J.-A.
- Bae I.-H.
- Jang W.-H.
- Kim J.-H.
- Bak S.-Y.
- Han S.-H.
- Park Y.-H.
- Lim K.-M.
Hydrogen peroxide and monoethanolamine are the key causative ingredients for hair dye-induced dermatitis and hair loss.
J. Dermatol. Sci. 2012; 66: 12-19
]. The GSK-3β/β-catenin signaling pathway plays an important role in the human dermal papilla cells (hDPCs) of the hair follicles (hHFs) [
- Shin S.Y.
- Kim C.G.
- Jho E.H.
- Rho M.S.
- Kim Y.S.
- Kim Y.H.
- Lee Y.H.
Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin.
Cancer Lett. 2004; 212: 225-231
]. Here we used hHFs and hDPCs to investigate the effects of H2O2 on hair growth via the GSK-3β/β-catenin signaling pathway.
- Enshell-Seijffers D.
- Lindon C.
- Kashiwagi M.
- Morgan B.A.
beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair.
Dev. Cell. 2010; 18: 633-642
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- Hydrogen peroxide and monoethanolamine are the key causative ingredients for hair dye-induced dermatitis and hair loss.J. Dermatol. Sci. 2012; 66: 12-19
- Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin.Cancer Lett. 2004; 212: 225-231
- beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair.Dev. Cell. 2010; 18: 633-642
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Published online: September 26, 2017
Received: September 1, 2016
© 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.