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Letter| Volume 89, ISSUE 1, P91-94, January 2018

Hydrogen peroxide (H2O2) suppresses hair growth through downregulation of β-catenin

  • Jungyoon Ohn
    Affiliations
    Department of Dermatology, College of Medicine, Seoul National University, Seoul, Republic of Korea, Republic of Korea

    Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
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  • So Jeong Kim
    Affiliations
    Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea

    Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
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  • Soon-Jin Choi
    Affiliations
    Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea

    Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
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  • Yun Seon Choe
    Affiliations
    Department of Dermatology, College of Medicine, Seoul National University, Seoul, Republic of Korea, Republic of Korea
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  • Ohsang Kwon
    Affiliations
    Department of Dermatology, College of Medicine, Seoul National University, Seoul, Republic of Korea, Republic of Korea

    Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea

    Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
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  • Kyu Han Kim
    Correspondence
    Corresponding author a: Department of Dermatology, Seoul National University College of Medicine, 101 Daehak−ro, Jongno−gu, Seoul 110−744, Republic of Korea.
    Affiliations
    Department of Dermatology, College of Medicine, Seoul National University, Seoul, Republic of Korea, Republic of Korea

    Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea

    Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    Search for articles by this author
Published:September 26, 2017DOI:https://doi.org/10.1016/j.jdermsci.2017.09.003
Hydrogen peroxide (H2O2) suppresses hair growth through downregulation of β-catenin
Previous ArticleDifferential expression of CCR4 in primary cutaneous gamma/delta (γ⁄δ) T cell lymphomas and mycosis fungoides: Significance for diagnosis and therapy
Next ArticleAnacardic acid reduces lipogenesis in human differentiated adipocytes via inhibition of histone acetylation
      Hair dyes are frequently used to meet cosmetic needs. With their increased usage, many patients visit dermatologists complaining of the adverse event of hair dye–induced hair loss, which is induced by oxidative stress caused by the hydrogen peroxide (H2O2) in the dye [
      • Seo J.-A.
      • Bae I.-H.
      • Jang W.-H.
      • Kim J.-H.
      • Bak S.-Y.
      • Han S.-H.
      • Park Y.-H.
      • Lim K.-M.
      Hydrogen peroxide and monoethanolamine are the key causative ingredients for hair dye-induced dermatitis and hair loss.
      J. Dermatol. Sci. 2012; 66: 12-19
      ]. The oxidative stress caused by H2O2 is considered cytotoxic in animals, plants, and cultured cells. Despite its cytotoxic effects, H2O2 is required to modulate inter- and intracellular signaling pathways, including the β-catenin pathway [
      • Shin S.Y.
      • Kim C.G.
      • Jho E.H.
      • Rho M.S.
      • Kim Y.S.
      • Kim Y.H.
      • Lee Y.H.
      Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin.
      Cancer Lett. 2004; 212: 225-231
      ]. The GSK-3β/β-catenin signaling pathway plays an important role in the human dermal papilla cells (hDPCs) of the hair follicles (hHFs) [
      • Enshell-Seijffers D.
      • Lindon C.
      • Kashiwagi M.
      • Morgan B.A.
      beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair.
      Dev. Cell. 2010; 18: 633-642
      ]. Here we used hHFs and hDPCs to investigate the effects of H2O2 on hair growth via the GSK-3β/β-catenin signaling pathway.
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      Article info

      Publication history

      Published online: September 26, 2017
      Received: September 1, 2016

      Identification

      DOI: https://doi.org/10.1016/j.jdermsci.2017.09.003

      Copyright

      © 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

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