The dermis is divided into the papillary and reticular dermis. The upper layer, the
papillary dermis, is about 200 μm-thick, located just below the epidermis, and characterized by relatively thin and
sparse fibers. The underlying layer, the reticular dermis, is composed of solid tissue
made up of thicker highly dense fibers. The extracellular matrix components of the
two layers differ [
[1]
]. The matrix is synthesized by fibroblasts, and the fibroblasts in the two layers
have different properties. Fibroblasts from the papillary and reticular dermis exhibit
different proliferative capacities, morphologies and cell surface markers [
2
,
3
]. Thus, the dermis has a layered structure in which each layer has its own matrix
and cells and is considered to play distinct roles. However, the process responsible
for this layered structure remains unknown. Studying the properties of the cells and
matrix in each layer is important for understanding the function of the dermis.To read this article in full you will need to make a payment
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Article info
Publication history
Published online: October 18, 2017
Accepted:
October 14,
2017
Received in revised form:
September 11,
2017
Received:
October 13,
2016
Identification
Copyright
© 2018 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.
