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Letter to the Editor| Volume 88, ISSUE 2, P254-256, November 2017

Characterization of a novel canine T-cell line established from a dog with cutaneous T-cell lymphoma

Published:June 26, 2017DOI:https://doi.org/10.1016/j.jdermsci.2017.06.001
Characterization of a novel canine T-cell line established from a dog with cutaneous T-cell lymphoma
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      Highlights

      • •
        Canine cutaneous T-cell lymphoma (CTCL) has the potential to be used as a model animal for human primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma (CD8+PCECTL).
      • •
        A novel canine CTCL cell line, termed EO-1, was established from a dog with CTCL.
      • •
        EO-1 expressed CD3 and CD8 with a high expression of a functional CC chemokine receptor 4 that was biologically active to both human and mouse CCL17/TARC.
      • •
        EO-1 may be a useful tool in the research for not only canine CTCL but also human CD8+PCECTL.
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      Article info

      Publication history

      Published online: June 26, 2017
      Received: January 6, 2017

      Identification

      DOI: https://doi.org/10.1016/j.jdermsci.2017.06.001

      Copyright

      © 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

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