- •Canine cutaneous T-cell lymphoma (CTCL) has the potential to be used as a model animal for human primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma (CD8+PCECTL).
- •A novel canine CTCL cell line, termed EO-1, was established from a dog with CTCL.
- •EO-1 expressed CD3 and CD8 with a high expression of a functional CC chemokine receptor 4 that was biologically active to both human and mouse CCL17/TARC.
- •EO-1 may be a useful tool in the research for not only canine CTCL but also human CD8+PCECTL.
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Published online: June 26, 2017
Received: January 6, 2017
© 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.