If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. You will then receive an email that contains a secure link for resetting your password
If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password
Atopic dermatitis (AD) is a relapsing chronic inflammatory pruritic skin disorder
that has been partially attributed to skin barrier dysfunction. Skin barrier function
has previously been estimated by measuring skin hydration and transepidermal water
loss (TEWL), and low levels of skin hydration and high levels of TEWL have been reported
in AD patients. N-acetylcysteine (NAC) is a thiol derivative that stimulates the synthesis
of glutathione, an internal antioxidant. Previous studies reported that NAC was useful
for treating skin diseases such as toxic epidermal necrolysis and lamellar ichthyosis.
In the present study, we assessed the clinical effects of topical NAC on skin hydration
and TEWL in healthy volunteers and AD patients. Ten healthy volunteers and 11 AD patients
were enrolled. NAC solution (20 w/v%) or its control vehicle was applied to the skin of the forearm twice a day for
4 weeks. Skin hydration and TEWL in the forearm were measured before and after the
topical application of NAC solution. The topical application of NAC for 4 weeks increased
skin hydration in 9/10 healthy volunteers and decreased TEWL in 8/10 healthy volunteers.
Topical application of the control vehicle for 4 weeks decreased skin hydration in
8/11 AD patients. The topical application of NAC increased skin hydration in 9/11
AD patients and decreased TEWL in 9 AD patients. Recently, we have reported that NAC
restored the expression of some cell adhesion molecules that contribute to forming
the skin barrier in a mouse model of AD by reducing oxidative stress. Therefore, the
topical application of NAC may have increased skin hydration and decreased TEWL by
strengthening the function of this barrier. Our results may also support the possibility
of NAC restoring skin barrier function.
To read this article in full you will need to make a payment