Abstract
Our study suggested that surgical damage of the lymphatic system promotes tumor progression
via impaired immune response. However, as pointed out by Valerio et al, lymph stasis
is likely to induce immune stasis, resulting in not only enhanced tumor growth but
also tumor generation. Although mechanisms of the tumor generation may not only include
impaired immune response but also other factors induced by lymph stasis, we should
avoid unnecessary lymphatic disruption in any surgeries and carefully consider the
flap design to minimalize lymphatic disruption even in cases with benign tumors.
Keywords
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References
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Article info
Publication history
Published online: February 15, 2018
Accepted:
February 12,
2018
Received:
February 2,
2018
Identification
Copyright
© 2018 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.
