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Current understanding of the role of dietary lipids in the pathophysiology of psoriasis

  • Tetsuya Honda
    Correspondence
    Corresponding author at: Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara, Sakyo, Kyoto, 606-8507, Japan.
    Affiliations
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Japan
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  • Kenji Kabashima
    Affiliations
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Japan

    Singapore Immunology Network (SIgN) and Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A⁎STAR), Biopolis, Singapore
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      Abstract

      Dietary lipids are fundamental nutrients for human health. They are typically composed of various long-chain fatty acids which include saturated fatty acids (SFAs) and unsaturated fatty acids (UFAs). UFAs are further classified into several groups, such as omega-3 polyunsaturated fatty acids (PUFAs) and omega-6 PUFAs, depending on their chemical structure. Epidemiological studies have suggested the involvement of dietary lipids in the progression or regulation of psoriasis, a common chronic inflammatory skin disease induced via the IL-23/IL-17 axis. Although the underlying mechanisms by which dietary lipids regulate psoriasis have remained unclear, with the advancement of experimental techniques and the development of psoriasis mouse models, various possible mechanisms have been proposed. For example, SFAs may facilitate psoriatic dermatitis by causing activation of the inflammasome in keratinocytes and macrophages or by inducing IL-17-producing cells, such as Th17 and IL-17-producing γδ T cells in the skin, while omega-3 PUFAs may play inhibitory roles by suppressing Th17 differentiation. In this review, we summarize current data on the roles of dietary lipids in the development of psoriasis as revealed by mouse studies, and we discuss potential therapeutic strategies for psoriasis from the perspective of dietary lipids.

      Keywords

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      Biography

      Tetsuya Honda (M.D., Ph.D.) received the M.D. in 2000 and Ph.D. in 2007 from Kyoto University, Kyoto, Japan. He was assigned as an Assistant Professor at Kyoto University (2007–2010) and a Visiting Fellow at National Institute of Health, Bethesda (2010–2012). After returning to Japan, he served as a Program-Specific Associate Professor (2012–2015) at Department of Innovation Center for Immunoregulation Technologies and Drugs at Kyoto University, and is now working as Senior Lecturer at Department of Dermatology at Kyoto University. His research interest is in the field of cutaneous immunology, particularly atopic dermatitis, psoriasis, and contact dermatitis.