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Anti-pruritic and anti-inflammatory effects of natural verbascoside through selective inhibition of temperature-sensitive Ca2+-permeable TRPV3 channel

      Pruritus and inflammation are the most common symptoms in skin diseases, including eczema, atopic dermatitis and allergic contact dermatitis [
      • Steinhoff M.
      • Bíró T.
      A TR(I)P to pruritus research: role of TRPV3 in inflammation and itch.
      ]. The warm temperature-sensitive and calcium-permeable transient receptor potential vanilloid 3 (TRPV3) channel is abundantly expressed in the keratinocytes, and gain-of-function mutations of TRPV3 cause skin pruritus and inflammation in rodents and humans, suggesting that pharmacological inhibition of overactive TRPV3 may be beneficial for therapy of pruritus or dermatitis [
      • Wang G.
      • Wang K.
      The Ca2+ -Permeable cation transient receptor potential TRPV3 channel: an emerging pivotal target for itch and skin diseases.
      ].
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