LL37 is an autoantigen derived from keratinocytes that can bind to surface scavenger
receptors expressed on myeloid dendritic cells (DCs), plasmacytoid DCs, and macrophages
to recognize extracellular self-DNA [
[1]
]. Among such scavenger receptors, CD163 is a specific surface marker of macrophages
[
[2]
]. The expression of LL37 on myeloid cells in the dermis is controlled by proinflammatory
cytokines such as IL-17 and TNF-α [
[3]
]. Since Paget’s cells produce CCL20 and recruit Th17 in the lesional skin of EMPD
[
[4]
], the expression of LL37 in invasive EMPD might be increased after the dermal invasion
of Paget’s cells. Since TAMs in EMPD secrete an array of chemokines in lesional skin
[
[5]
], TAMs stimulated by LL37 might also play a critical role in the progression of EMPD.To read this article in full you will need to make a payment
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References
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- Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes.Exp Dermatol. 2017; 26: 1075-1082
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- Receptor Activator of NF-κB Ligand Promotes the Production of CCL17 from RANK+ M2 Macrophages.J Invest Dermatol. 2015; 135: 2884-2887
- The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis.Nat Commun. 2014; 5: 5621
- The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond.Front Immunol. 2018; 9: 1682
- The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis.Nat Commun. 2014; 5: 5621
- Tumor-associated macrophages: Therapeutic targets for skin cancer.Front Oncol. 2018; 8: 3
- CXCL13 is highly produced by Sézary cells and enhances their migratory ability via a synergistic mechanism involving CCL19 and CCL21 chemokines.Cancer Res. 2008; 68: 7137-7146
Article info
Publication history
Published online: May 16, 2020
Accepted:
May 1,
2020
Received in revised form:
April 14,
2020
Received:
January 22,
2020
Identification
Copyright
© 2020 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.
