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Letters to the Editor| Volume 103, ISSUE 1, P49-52, July 2021

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Progerin mRNA expression is elevated in aged human dermis and impairs TGF-β/Smad signaling

  • Author Footnotes
    1 Current address: Department of Dermatology, Third Xiangya Hospital, Central South, University, Changsha, China.
    ,
    Author Footnotes
    3 These authors contributed equally to this work.
    Yaping Xiang
    Footnotes
    1 Current address: Department of Dermatology, Third Xiangya Hospital, Central South, University, Changsha, China.
    3 These authors contributed equally to this work.
    Affiliations
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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  • Author Footnotes
    3 These authors contributed equally to this work.
    Zhaoping Qin
    Footnotes
    3 These authors contributed equally to this work.
    Affiliations
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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  • Chunfang Guo
    Affiliations
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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  • Tianyuan He
    Affiliations
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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  • Author Footnotes
    2 Current address: College of Life Science, Inner Mongolia Agriculture University, Hohhot, China.
    Yingchun Liu
    Footnotes
    2 Current address: College of Life Science, Inner Mongolia Agriculture University, Hohhot, China.
    Affiliations
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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  • Taihao Quan
    Correspondence
    Corresponding author at: Department of Dermatology, University of Michigan Medical School, 1301 Catherine, Medical Science I, Room 6447, Ann Arbor, Michigan, 48109-0609, USA.
    Affiliations
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Search for articles by this author
  • Author Footnotes
    1 Current address: Department of Dermatology, Third Xiangya Hospital, Central South, University, Changsha, China.
    2 Current address: College of Life Science, Inner Mongolia Agriculture University, Hohhot, China.
    3 These authors contributed equally to this work.
Published:April 25, 2021DOI:https://doi.org/10.1016/j.jdermsci.2021.04.005
Progerin mRNA expression is elevated in aged human dermis and impairs TGF-β/Smad signaling
Previous ArticleIntracellular oxidative stress induced by calcium influx initiates the activation of phagocytosis in keratinocytes accumulating at S-phase of the cell cycle after UVB irradiation
Next ArticleClinical characteristics of four myositis-specific autoantibodies with regulatory-approved testing in Japan: A Japanese multi-centre adult myositis patients’ cohort
      Lamins A/C, the products of the LMNA gene, are major structural components of the nuclear lamina, a dense fibrillar network attached to the inner nuclear membrane. The nuclear lamina physically interacts with the cytoskeleton and nucleoskeleton, and as a result plays an important role in maintaining nuclear morphology and providing mechanical support to the nucleus. As such, defects in the nuclear lamina disrupt the integrity of the nucleus, which can lead to alterations in cellular events such as chromatin organization, gene regulation, and signaling [
      • Dechat T.
      • Pfleghaar K.
      • Sengupta K.
      • Shimi T.
      • Shumaker D.K.
      • Solimando L.
      • et al.
      Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.
      Genes Dev. 2008; 22: 832-853
      ].

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      Article info

      Publication history

      Published online: April 25, 2021
      Accepted: April 23, 2021
      Received in revised form: April 20, 2021
      Received: February 17, 2021

      Identification

      DOI: https://doi.org/10.1016/j.jdermsci.2021.04.005

      Copyright

      © 2021 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.

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