Lamins A/C, the products of the LMNA gene, are major structural components of the nuclear lamina, a dense fibrillar network attached to the inner nuclear membrane. The nuclear lamina physically interacts with the cytoskeleton and nucleoskeleton, and as a result plays an important role in maintaining nuclear morphology and providing mechanical support to the nucleus. As such, defects in the nuclear lamina disrupt the integrity of the nucleus, which can lead to alterations in cellular events such as chromatin organization, gene regulation, and signaling [
- Dechat T.
- Pfleghaar K.
- Sengupta K.
- Shimi T.
- Shumaker D.K.
- Solimando L.
- et al.
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.
Genes Dev. 2008; 22: 832-853
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- Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.Genes Dev. 2008; 22: 832-853
- Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.Nature. 2003; 423: 293-298
- Hutchinson-Gilford Progeria Syndrome: a premature aging disease caused by LMNA gene mutations.Ageing Res. Rev. 2017; 33: 18-29
- The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.PLoS One. 2007; 2: e1269
- Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging: a mini-review.Gerontology. 2015; 61: 427-434
- Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging.Arterioscler. Thromb. Vasc. Biol. 2010; 30: 2301-2309
- Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing.Nat. Cell Biol. 2008; 10: 452-459
- Progeria syndromes and ageing: what is the connection?.Nat. Rev. Mol. Cell Biol. 2010; 11: 567-578
- A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.Proc. Natl. Acad. Sci. U. S. A. 2007; 104: 4949-4954
- Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence.BMC Cell Biol. 2017; 18: 31
Published online: April 25, 2021
Accepted: April 23, 2021
Received in revised form: April 20, 2021
Received: February 17, 2021
© 2021 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.