The Koebner phenomenon (KP) is defined as de novo development of isomorphic cutaneous lesions by external trauma, such as scratch,
pressure, and stretch, in the uninvolved skin of patients with cutaneous diseases
such as psoriasis. However, the mechanisms behind KP are not yet fully understood.
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References
- Signaling through purinergic receptors for ATP induces human cutaneous innate and adaptive Th17 responses: implications in the pathogenesis of psoriasis.J. Immunol. 2013; 190: 4324-4336
- ATP drives lamina propria T(H)17 cell differentiation.Nature. 2008; 455: 808-812
- The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures.J. Biol. Chem. 2009; 284: 21257-21264
- Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes.J. Invest. Dermatol. 2004; 122: 783-790
- Mechanical stretch exacerbates psoriasis by stimulating keratinocyte proliferation and cytokine production.J. Invest. Dermatol. 2019; 139: 1470-1479
Article info
Publication history
Published online: June 04, 2021
Accepted:
June 2,
2021
Received in revised form:
May 19,
2021
Received:
January 10,
2021
Identification
Copyright
© 2021 Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology.
