Chronic itch is the dominating symptom of atopic dermatitis (AD). Antihistamines have been used to reduce the intensity of itch caused by AD, but these agents are effective only in some patients [
]. Histidine decarboxylase (HDC) is the enzyme that catalyzes the synthesis of histamine. Previous studies on mice treated with topical surfactants show that an increase in epidermal HDC is associated with itch-related behavior [
- Murota H.
- Katayama I.
Assessment of antihistamines in the treatment of skin allergies.
Curr. Opin. Allergy Clin. Immunol. 2011; 11: 428-437
] and chronic pruritus with unknown cause induces monkey epidermal HDC [
- Inami Y.
- Sasaki A.
- Andoh T.
- Kuraishi Y.
Surfactant-induced chronic pruritus: role of L-histidine decarboxylase expression and histamine production in epidermis.
Acta Derm. Venereol. 2014; 94: 645-650
]. These findings suggest that increased HDC expression in the epidermis plays a role in itch. In this study, we investigated the correlation between epidermal HDC and visual analogue scale (VAS; score range: 0–10) in patients with AD and identified the cells expressing HDC in the epidermis.
- Inami Y.
- Nattkemper L.A.
- Sakai K.
- Yosipovitch G.
- Akiyama T.
Expression of histidine decarboxylase in the epidermis of primates with chronic itch.
Acta Derm. Venereol. 2017; 97: 739-740
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- Assessment of antihistamines in the treatment of skin allergies.Curr. Opin. Allergy Clin. Immunol. 2011; 11: 428-437
- Surfactant-induced chronic pruritus: role of L-histidine decarboxylase expression and histamine production in epidermis.Acta Derm. Venereol. 2014; 94: 645-650
- Expression of histidine decarboxylase in the epidermis of primates with chronic itch.Acta Derm. Venereol. 2017; 97: 739-740
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Published online: June 10, 2021
Accepted: June 8, 2021
Received in revised form: May 20, 2021
Received: February 10, 2021
© 2021 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.